Protein Info for RR42_RS34880 in Cupriavidus basilensis FW507-4G11

Annotation: multidrug transporter MatE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 506 signal peptide" amino acids 1 to 37 (37 residues), see Phobius details transmembrane" amino acids 60 to 83 (24 residues), see Phobius details amino acids 96 to 117 (22 residues), see Phobius details amino acids 137 to 157 (21 residues), see Phobius details amino acids 169 to 190 (22 residues), see Phobius details amino acids 197 to 221 (25 residues), see Phobius details amino acids 243 to 271 (29 residues), see Phobius details amino acids 292 to 314 (23 residues), see Phobius details amino acids 326 to 345 (20 residues), see Phobius details amino acids 365 to 386 (22 residues), see Phobius details amino acids 393 to 412 (20 residues), see Phobius details amino acids 424 to 444 (21 residues), see Phobius details TIGR00797: MATE efflux family protein" amino acids 24 to 426 (403 residues), 243.4 bits, see alignment E=1.9e-76 PF01554: MatE" amino acids 24 to 185 (162 residues), 107.6 bits, see alignment E=5.4e-35 amino acids 253 to 415 (163 residues), 92.5 bits, see alignment E=2.4e-30 PF14667: Polysacc_synt_C" amino acids 138 to 231 (94 residues), 49.7 bits, see alignment E=4.4e-17

Best Hits

Swiss-Prot: 40% identical to YOEA_BACSU: Probable multidrug resistance protein YoeA (yoeA) from Bacillus subtilis (strain 168)

KEGG orthology group: None (inferred from 83% identity to reh:H16_B2055)

Predicted SEED Role

"Multidrug and toxin extrusion (MATE) family efflux pump YdhE/NorM, homolog"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YNC4 at UniProt or InterPro

Protein Sequence (506 amino acids)

>RR42_RS34880 multidrug transporter MatE (Cupriavidus basilensis FW507-4G11)
MPTKSKAQLTTGPIGRTLLLFSLPVLGSNILQSLNASINSVWVGHFLGEAALTATSNANI
ILFFLLGVVFGISMANTIMIGQAVGARDLVEARRVVGTSTTFFILLSVLAAALGYAFTPD
ILAAMGTPADARALAISYLRIIFLALPFMYFYNFVMMTLRGAGDSRTPFYFMLLSVGLDV
VLNPLLIFGIGPFPELGIAGSALSTLIAQLASLAAMLIVLYRRHHFLALRRHQLAYLRPD
TAILRALVAKGLPMGLQMVVISSSAIVMMSLVNRYGSQTTAAYGVASQLWTYVQMPALAV
GASVSSMVAQNVGAGLWDRVTRITRVGLLFNLLMTGALVALIYLFNRHSLGLFLPDDGTA
IGIAQHINAIVLWSFILFGFTIVLFGTVRATGAVMAPLVILFLSMWVVRLPFAWVLERTV
GADAIWWSFPLGSVVSVTLAVAYYRFGNWRAAHILPVAPGPAPEPEFAAQAPDTSMGTAC
EEALSTAGAAGEQALAGKSPAPAEAH