Protein Info for RR42_RS30950 in Cupriavidus basilensis FW507-4G11

Annotation: cation transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1042 transmembrane" amino acids 12 to 31 (20 residues), see Phobius details amino acids 346 to 363 (18 residues), see Phobius details amino acids 369 to 389 (21 residues), see Phobius details amino acids 395 to 414 (20 residues), see Phobius details amino acids 452 to 472 (21 residues), see Phobius details amino acids 484 to 508 (25 residues), see Phobius details amino acids 530 to 555 (26 residues), see Phobius details amino acids 881 to 900 (20 residues), see Phobius details amino acids 907 to 926 (20 residues), see Phobius details amino acids 932 to 957 (26 residues), see Phobius details amino acids 981 to 1001 (21 residues), see Phobius details amino acids 1010 to 1033 (24 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1041 (1041 residues), 1771.9 bits, see alignment E=0 PF00873: ACR_tran" amino acids 6 to 1037 (1032 residues), 1189.9 bits, see alignment E=0

Best Hits

Swiss-Prot: 82% identical to CZCA_ALCSC: Cation efflux system protein CzcA (czcA) from Alcaligenes sp. (strain CT14)

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 79% identity to axy:AXYL_04676)

MetaCyc: 72% identical to cation efflux system protein (Pseudomonas putida KT2440)
RXN1G01-61; TRANS-RXN0-200; TRANS-RXN0-244

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YNR2 at UniProt or InterPro

Protein Sequence (1042 amino acids)

>RR42_RS30950 cation transporter (Cupriavidus basilensis FW507-4G11)
MFERLIRFAIEQRWLVLLAVVAMAALGIYNYSRLPIDAVPDITNVQVQVNTSAPGYSPLE
TEQRVTYPIETAMSGLPGLEQTRSLSRYGLSQVTVIFKDGTDIYFARQLVNQRIQEAAQN
LPTGVAPQMGPISTGLGEIYLWTVEAEDGARKADGTPYTPTDLREIQDWVIKPQLRTVPG
VTEINSIGGFAKEYLVAPSPERMASYGLSLQDVVVALEKNNANVGAGYIERRGEQYLVRA
PGQVRSVDDIREIIVGSAQGQPIRIRDLADVGIGRELRTGAATDNGREVVLGTVFMLIGE
NSRAVSQAVDQRMAAINRSLPAGVKAVTVYDRTVLVDRAIATVKKNLVEGAILVIVILFL
FLGNLRAAIITALVIPLSMLFTFTGMVTYKISANLMSLGALDFGIIIDGAVVIVENCVRR
LAHAQQQHGRPLTRGERFHEVFAASREARRPLIFGQLIIMIVYIPIFALTGVEGKMFHPM
AMTVVLALIGAMILSVTFVPAAVALFIGDKVAEKENRLMLWAKRAYAPMLGKTIANTPVV
LTLAAVAVLLSGLVATRLGSEFIPNLNEGDFAVQALRIPGTSLTQSLAMQQQIETRLKEK
FPEIERVFARTGTAEIASDPMPPNASDGYIMLRPRAKWPDPSKTREQLLAQMEAELATIP
GNRYEFSQPIQLRFNELISGVRSDVAVKIFGDDNAVLEDTAQKVATVLRAVPGATEVKVE
QTSGLPMLTVDVDRARAARYGLNMIDVQDTVAIAVGGRDAGIFFQGDRRFNIGVRLPEGI
RGDVEALRRLPIPLPKGSTAAASYIPLGEVATLTLAPGPNQVSRENGKRRIVVSANVRGR
DVGTFVPEAMASLDRQVKVPAGYWVTWGGTFEQLQSAATRLQIVVPVALLMVFVLLFAMF
GNVRDGLLVFTGIPFALTGGILALWLRGIPLSISAAVGFIALSGVAVLNGLVMLSFIRSL
REDGKPLDEAIHTGALTRLRPVLMTALVASLGFIPMAIATGTGAEVQRPLATVVIGGILS
STALTLLVLPVLYRLAHRRDKD