Protein Info for RR42_RS30655 in Cupriavidus basilensis FW507-4G11

Annotation: LysR family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 307 PF00126: HTH_1" amino acids 5 to 62 (58 residues), 72 bits, see alignment E=3.1e-24 PF03466: LysR_substrate" amino acids 88 to 293 (206 residues), 144.1 bits, see alignment E=4.1e-46

Best Hits

KEGG orthology group: K03576, LysR family transcriptional regulator, regulator for metE and metH (inferred from 90% identity to reh:H16_B1580)

Predicted SEED Role

"Transcriptional activator MetR" in subsystem Methionine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YDF0 at UniProt or InterPro

Protein Sequence (307 amino acids)

>RR42_RS30655 LysR family transcriptional regulator (Cupriavidus basilensis FW507-4G11)
MIEVRHLRSLVAIAESGKLATAAERVHVSQSALSHQIKGIEAHYGLPLFDRTRQGLRFTP
AGDRLLVLAREMLAAISTAERDLARLKGDTRGELRIVLECHTCFDWLMPVMDEFRRRWPE
VEVDLVAGFHADPLALLAEGRTDMVIGSMPAAKRGLAVAPLFRFEILAVIANEHRLRNKR
RVEAADLDGETLITYPVPDQRIDLIREVLEPAGIKLQRRTAELTVAVLQLVASRRGVAAL
PNWGVKNYVDHDYVLAKRIGAKGLWSELYATTPAPLAQRPYVRDFVSIVRDTCAAELDGI
ELLPEGE