Protein Info for RR42_RS28940 in Cupriavidus basilensis FW507-4G11

Annotation: Bcr/CflA family drug resistance efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 406 signal peptide" amino acids 1 to 43 (43 residues), see Phobius details transmembrane" amino acids 52 to 71 (20 residues), see Phobius details amino acids 83 to 101 (19 residues), see Phobius details amino acids 107 to 128 (22 residues), see Phobius details amino acids 140 to 164 (25 residues), see Phobius details amino acids 170 to 187 (18 residues), see Phobius details amino acids 220 to 243 (24 residues), see Phobius details amino acids 256 to 278 (23 residues), see Phobius details amino acids 290 to 309 (20 residues), see Phobius details amino acids 315 to 337 (23 residues), see Phobius details amino acids 349 to 370 (22 residues), see Phobius details amino acids 376 to 395 (20 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 13 to 392 (380 residues), 320.9 bits, see alignment E=7.8e-100 PF07690: MFS_1" amino acids 22 to 364 (343 residues), 154.3 bits, see alignment E=4.1e-49 PF00083: Sugar_tr" amino acids 53 to 184 (132 residues), 24.7 bits, see alignment E=1.1e-09

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 79% identity to reh:H16_B1232)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YL50 at UniProt or InterPro

Protein Sequence (406 amino acids)

>RR42_RS28940 Bcr/CflA family drug resistance efflux transporter (Cupriavidus basilensis FW507-4G11)
MTRSTRAPQSARFPLWLLVCASLTALAPLSIDMYLPSFPALAGDLGVDIGRVQLTLGTFL
VGLAVGQAFYGPISDRFGRKPPLYVGLLAYASAAAGCALARDVDALMLWRFLQALGGCAG
MVMARAVIRDRLEAHESARAFSSLMLVMGLAPILAPIIGGAVLAAFGWRAIFWLLCGASL
LILWVVHRYMEESLDHASAMPLRLGRVLSNYGELLRDRGFVGYSLSAGCAQAGMFAYIAG
SPFVLIELHGIDPSHYGFVFGANALGLIGMSQLNARLVRNRTLDHVLRRALLAPCLAGLV
LAAAVLAGMAPLPVLLTGFFVFIASLGCILPNASALAMDQQGHRAGTASALMGTLQFSLG
TLAGAAVSFWRDGSALPLAVVMGVCGTGAVLMRAFGRSGATVRGAG