Protein Info for RR42_RS28895 in Cupriavidus basilensis FW507-4G11

Annotation: acetone carboxylase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 774 PF02538: Hydantoinase_B" amino acids 50 to 629 (580 residues), 376.7 bits, see alignment E=8.4e-117

Best Hits

Swiss-Prot: 70% identical to ACXB_XANP2: Acetone carboxylase alpha subunit (acxB) from Xanthobacter autotrophicus (strain ATCC BAA-1158 / Py2)

KEGG orthology group: K10854, acetone carboxylase, alpha subunit [EC: 6.4.1.6] (inferred from 94% identity to bph:Bphy_6151)

MetaCyc: 70% identical to acetone carboxylase alpha subunit (Xanthobacter autotrophicus Py2)
Acetone carboxylase. [EC: 6.4.1.6]

Predicted SEED Role

"Acetone carboxylase, alpha subunit (EC 6.4.1.6)" (EC 6.4.1.6)

MetaCyc Pathways

Isozymes

Compare fitness of predicted isozymes for: 6.4.1.6

Use Curated BLAST to search for 6.4.1.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YL40 at UniProt or InterPro

Protein Sequence (774 amino acids)

>RR42_RS28895 acetone carboxylase subunit alpha (Cupriavidus basilensis FW507-4G11)
MNMMSSKEVGLADLLKTGETLKQFRDAILERTAETGHYNGLTRLAFRERDPIRYEKLFSK
LRGGLVHARETAKKIAASPIVEQEGELCFTLYNAAGDCVLTSTGIIIHVGTMGAAIKYMI
ENDWETNPGIHPGDMFTNNDCAIGNVHPCDIATIVPIFAHGKLVGWVGGVTHVIDTGAVT
PGSMSTGQVQRFGDGYMITCRKTGVNDTPLRDWLHESQRSVRTPKYWILDERTRIAGCHM
IRDLIEEVIEDEGLQAYEEFSYEVIEEGRRGLQTRIKAMTLPGKYRKVAFVDVPYNHPDV
QTSSAFAKLDSIMHSPVEMEIRKDGSWRLDFEGASRWGWHSYNAHHVAFTSGIWVMMTQT
LVPTQRINDGAYFGTEFHLPKGTWMNPDDRRTGHAYAWHFLVSGWSAMWRGLSQAYFSRG
YLEEVNAGNANTSNWLQGGGINQEGEIHAVNSFEASSCGTGASAIKDGLNHAAAIWNPEG
DMGDIEIWEMAEPLLYLGRNAKANSGGYGKYRGGCGFETLRMVWKAQDWTMFFMGNGYMN
SDWGLMGGYPAATGYRFEAHKTGLKERIAAGDSLPLGGDANPDLPDYENHLNAGAVVKRD
QQCMTTEDCYDNYDLYLNYLRGGPGFGDPLDREVEAIERDLNNALLLPEYAQKVYGAVAT
KDGNGIWKVDAKQTALLRIEIRNQRLARSQPVQEWMKGERERILVKHASIQVRHMFATSF
GLSSKFEQQFRTFWGLPDSWTLTEDELDVPTYGSKYRMDLSKMPDVNTVVLVEE