Protein Info for RR42_RS28275 in Cupriavidus basilensis FW507-4G11

Annotation: short-chain dehydrogenase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 254 PF00106: adh_short" amino acids 10 to 199 (190 residues), 153.5 bits, see alignment E=7.4e-49 PF08659: KR" amino acids 13 to 174 (162 residues), 58.5 bits, see alignment E=1.3e-19 PF13561: adh_short_C2" amino acids 18 to 253 (236 residues), 180.2 bits, see alignment E=7.8e-57

Best Hits

Swiss-Prot: 39% identical to DHRS2_HUMAN: Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2) from Homo sapiens

KEGG orthology group: None (inferred from 81% identity to reh:H16_B1140)

Predicted SEED Role

"FIG00974312: hypothetical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YMA3 at UniProt or InterPro

Protein Sequence (254 amino acids)

>RR42_RS28275 short-chain dehydrogenase (Cupriavidus basilensis FW507-4G11)
MQNLFDLSGRVAVITGSTKGMGLEMARALGACGAALVVSGRDQATSEAVAAALDGEGFKA
KGIACDIGNVESVQAFARQALDAYGRVDALVLNAAGSGAAGALLSQGPDVLEQAMAGNVR
GNLVLVNALAPQMIERGDGAVIFMSSIAAKRGSAMLGMYSITKAATDGAVRSLALELGPK
GINVNAINPGPVRTEFSREALWGNPEQEARLAAAIPMRRIGEAKDVAGLAVLLASPAGRF
IHGQSIGVDGGLSA