Protein Info for RR42_RS27055 in Cupriavidus basilensis FW507-4G11

Annotation: membrane protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1046 signal peptide" amino acids 1 to 31 (31 residues), see Phobius details transmembrane" amino acids 333 to 353 (21 residues), see Phobius details amino acids 359 to 380 (22 residues), see Phobius details amino acids 386 to 409 (24 residues), see Phobius details amino acids 431 to 452 (22 residues), see Phobius details amino acids 464 to 489 (26 residues), see Phobius details amino acids 521 to 542 (22 residues), see Phobius details amino acids 858 to 877 (20 residues), see Phobius details amino acids 885 to 904 (20 residues), see Phobius details amino acids 911 to 932 (22 residues), see Phobius details amino acids 961 to 979 (19 residues), see Phobius details amino acids 990 to 1014 (25 residues), see Phobius details TIGR00914: heavy metal efflux pump, CzcA family" amino acids 1 to 1025 (1025 residues), 928.6 bits, see alignment E=2.3e-283 PF00873: ACR_tran" amino acids 7 to 1015 (1009 residues), 826.1 bits, see alignment E=4.1e-252 PF03176: MMPL" amino acids 855 to 1018 (164 residues), 26.5 bits, see alignment E=3.1e-10

Best Hits

KEGG orthology group: K07239, heavy-metal exporter, HME family (inferred from 78% identity to dia:Dtpsy_3517)

Predicted SEED Role

"Cobalt-zinc-cadmium resistance protein CzcA; Cation efflux system protein CusA"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YIM0 at UniProt or InterPro

Protein Sequence (1046 amino acids)

>RR42_RS27055 membrane protein (Cupriavidus basilensis FW507-4G11)
MIDRLVTLCFNRRAIVWLVFALVALYGAYSWKQLPVEAYPDIADVTSQIVTQVPGLGAEE
IELQITIPLERALLATPGMHVLRTRSLFALSLITVVFEDGTDGYWARQRLQERLNEVDLP
YGAKPGLDPYTSPTGEFYRYTLESGTRDLRELSELQTWTVIPRLKKVRGVVDVTNFGGLT
TQFMLELDPARLTQYNLTLTQVTEALNANNVNAGGSVIDRGEQSYVVRGVGLLRSLDDMG
NVVVTSKDGTPVLVKDLGTLRYGNVERRGVLGKDDNPDTISGITLLLKDFNASQALEGVH
EAVRDLNDNLLPKDVKVVAYLDRTALIEATMRTVGFTLTEGMLLVGIVLLLFLGSPRAAL
IVALTIPLSLLIAFIFMYHLRIPANLLSLGAIDFGILVDGAVVLVENILRRREQDKDRAL
TPRDAIEATLQVARPMFFGMLVIVAAYLPLFSFERIEYKLFSPMAFAVGAALIGALIVAL
ALVPGLAWIAMRKPRRVFHNPVLDWLGVRYRAALERGIGRIRWVAASCALALACVLALGA
TIGRDFLPYLDEGSLWLQVQMPPGITLERASDMASELRRVTREFPEVSYVVTQTGRNDDG
TDYWTPSHIEASVGLHPYKTWASGMTKQQLIDKLAARYAQMPGYSVGFMQPMIDGVQDKL
SGAHSDLVVKVFGENLGDVRRIAGEVAAALRGVPGAADVAIDVEPPLPNLKIDLDRAAAA
RYGINAADVAELISTGIGGSPVGQLYVGEKSYDMTVRFPPAMRASASGVGDLMLSAANGA
KVPLAQVARISTVSGESVIVREMARRHIIVRLNVRERDLSGFLKQAQPAIERAVSYDHKR
IQIEWGGQFENLERAQARLAVILPMTLALMFVLLFAEFRNLRQPALVLLAVPLATIGGLA
ALHLRGMTLNVSSAVGFIALFGVAVLNGVLMISQINRLRAQNGLSLREAVIEGAASRMRP
VLMTATVAAIGLTPAMLARGLGSDVQRPLATVVVGGLFTATLLTLLLLPALYYLVEARAE
RAAQAARESETDAEGNAPATSAAGQA