Protein Info for RR42_RS26355 in Cupriavidus basilensis FW507-4G11

Annotation: multidrug MFS transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 454 signal peptide" amino acids 1 to 27 (27 residues), see Phobius details transmembrane" amino acids 49 to 68 (20 residues), see Phobius details amino acids 75 to 95 (21 residues), see Phobius details amino acids 103 to 124 (22 residues), see Phobius details amino acids 134 to 155 (22 residues), see Phobius details amino acids 162 to 182 (21 residues), see Phobius details amino acids 194 to 212 (19 residues), see Phobius details amino acids 218 to 238 (21 residues), see Phobius details amino acids 259 to 284 (26 residues), see Phobius details amino acids 296 to 314 (19 residues), see Phobius details amino acids 323 to 343 (21 residues), see Phobius details amino acids 350 to 368 (19 residues), see Phobius details amino acids 388 to 412 (25 residues), see Phobius details amino acids 418 to 440 (23 residues), see Phobius details PF07690: MFS_1" amino acids 13 to 401 (389 residues), 177.2 bits, see alignment E=2.3e-56

Best Hits

KEGG orthology group: K08169, MFS transporter, DHA2 family, multidrug resistance protein (inferred from 80% identity to rme:Rmet_4542)

Predicted SEED Role

"putative transport protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YIB2 at UniProt or InterPro

Protein Sequence (454 amino acids)

>RR42_RS26355 multidrug MFS transporter (Cupriavidus basilensis FW507-4G11)
MTPLERRGMAAILVAVSLATLDTAIANTALPNIAASLHATPAASVWVINAYQLAMVATLL
PFAALGGIVGHRRVYLGGLMLFIAASVVCALSWSLPTLVAARLLQGVGASAIMSVNAALI
SAIFPPHRLGRGVGLNALVVGVSFAVGPTVASIILSLGPWPWLFAVNLPIGLLALYIAWP
ALPRTMRGAHRFDRVAAGLNVVMFASLIFALGEGAQRAPLGQSLAALALFLVAFVLMLRR
ERGHPAPMLPVDLLKRPMFALSTMTAICSFAAQGLAFVSLPFYFESVLGRSPIETGFLMT
PWSAVVALMAPLAGRLSDRYAPGLLGGVGLAVMCMGMASLALLPAHPSALDIGIRMAICG
AGFGFFQSPNLKALMSSAPRERAGGASGVIATARLLGQATGAALVALSFGIAGRYGPTLA
LAIGAGFAGVASIASGLRLITREAGAAALQPTGK