Protein Info for RR42_RS26100 in Cupriavidus basilensis FW507-4G11

Annotation: pyridine nucleotide-disulfide oxidoreductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF07992: Pyr_redox_2
  • amino acids 17 to 356 (340 residues), 179.7 bits, E=2.7e-56
• PF00070: Pyr_redox
  • amino acids 184 to 265 (82 residues), 41.2 bits, E=5.8e-14

Best Hits

KEGG orthology group: K03885, NADH dehydrogenase [EC: 1.6.99.3] (inferred from 80% identity to vap:Vapar_5340)

Predicted SEED Role

"NADH dehydrogenase (EC 1.6.99.3)" in subsystem Carboxysome or Respiratory dehydrogenases 1 (EC 1.6.99.3)

MetaCyc Pathways

• aerobic respiration III (alternative oxidase pathway) (3/3 steps found)
• NADH to cytochrome bo oxidase electron transfer I (2/2 steps found)
• aerobic respiration I (cytochrome c) (3/4 steps found)
• NADH to cytochrome bd oxidase electron transfer I (1/2 steps found)
• NAD(P)/NADPH interconversion (3/6 steps found)
• Fe(II) oxidation (2/6 steps found)

KEGG Metabolic Maps

• Oxidative phosphorylation

Isozymes

Compare fitness of predicted isozymes for: 1.6.99.3

Use Curated BLAST to search for 1.6.99.3

Sequence Analysis Tools

See A0A0C4YI84 at UniProt or InterPro

Protein Sequence (452 amino acids)

>RR42_RS26100 pyridine nucleotide-disulfide oxidoreductase (Cupriavidus basilensis FW507-4G11)
MKPSTYRPDARLKAPHRIVIVGGGAGGLELATRLGNTLGRRRQAEVTLIEKTRTHVWKPK
LHEIAAGSMDMSAHEVGYLAQSHWHHFRYRVGEMVGLDRERQEVLVAPYVDDEGTQITPP
RTFGYDTLIIAVGSQSNDFGTPGVYEHAMRLESAADALRFHSRMVNACIRAHAQTAPLLA
QQLHVAIIGAGATGVELAAELHRTTREVVAFGLDRVDADKDIRVTLIEAAPRVLPALPPR
LSSATEGLLRKLGVEVLTDAKVAEVLPGGVLLGDGRLLPAELVVWAAGVKAPDFLKDLAG
LETNRINQLVVNPTLQASRDENIFAIGDCAACAWPEANQGKGGFVPPRAQAAHQQASHMV
RQVRARMAGKPLADYRYRDFGSLVSLGEFSTVGNMMGGLIGGSLMVEGLFARMMYLSLYK
MHELALHGFAKVALDTLARSIVRRTEPHVKLH