Protein Info for RR42_RS23115 in Cupriavidus basilensis FW507-4G11

Annotation: serine hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 569 PF00144: Beta-lactamase" amino acids 5 to 330 (326 residues), 244.8 bits, see alignment E=1.4e-76 PF11954: DUF3471" amino acids 375 to 471 (97 residues), 54.5 bits, see alignment E=1.3e-18

Best Hits

KEGG orthology group: None (inferred from 63% identity to vpe:Varpa_3387)

Predicted SEED Role

"Beta-lactamase (EC 3.5.2.6)" in subsystem Beta-lactamase or Tn552 (EC 3.5.2.6)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.6

Use Curated BLAST to search for 3.5.2.6

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y9D7 at UniProt or InterPro

Protein Sequence (569 amino acids)

>RR42_RS23115 serine hydrolase (Cupriavidus basilensis FW507-4G11)
MLSDFDDLVQASMQEWKVPGLALAVIRDGETVLAKGYGVRDTEASAPVTADTQFLLCSLT
KSFTAAGLGLLVDERKLDWTRPVRDYIPEFRLHDAVATERVTVRDLLCHHSGVPRHDWIH
SPGDLSMVQILAALRHLEPSRDVREAYQYQNLGYLVAGQIAQRISGQRWEDFTTERLLRP
LGFAHFGLSIEALAAAPNHAHPHIMQGDESQRAMLTPIRALPAGGLNACVSDLAKWMRLL
IDEGTVDGKPLLSADIVRQMMTPRVHVGRSVFKEVGEFHYGLGLSLEHYRGERKVSHTGS
WVGWGNAMTMLPERRIGIAVLTNRAPSAVTELLTYHALDQLCGHKPIDWFDRFRTMRRQA
LAQQKVDQQARSELRRTGTTPSHPLDDYAGEYEHPAYGRIGITKENNALAWRWRGMSGQL
EHRHYDVFVTPDKPAEIHPDNLALSFGYDREGNIDRICAPLEPMVADIVFRRAAGGDVLD
PAFRALCAGSFMHGMQEISVTLDAAGQLSLRIDERQSWPLRPFDRRTFDLEGLQGYRVAF
RRPSPDIVDAVIFYQPDGTFLALRQAVPA