Protein Info for RR42_RS21065 in Cupriavidus basilensis FW507-4G11

Annotation: diguanylate phosphodiesterase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 538 signal peptide" amino acids 1 to 20 (20 residues), see Phobius details transmembrane" amino acids 243 to 261 (19 residues), see Phobius details PF12792: CSS-motif" amino acids 23 to 160 (138 residues), 48.6 bits, see alignment E=7e-17 PF00563: EAL" amino acids 273 to 505 (233 residues), 199 bits, see alignment E=8.1e-63

Best Hits

Predicted SEED Role

"diguanylate cyclase/phosphodiesterase (GGDEF & EAL domains) with PAS/PAC sensor(s)" in subsystem Bacterial hemoglobins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YIJ5 at UniProt or InterPro

Protein Sequence (538 amino acids)

>RR42_RS21065 diguanylate phosphodiesterase (Cupriavidus basilensis FW507-4G11)
MAALLAAGLALWLIAMLAAHDARERVERMSSAVRDNLELALADTLDIAYQDRELVGAPCR
GVARQLQEQGAYTAYIRDVVLVARGMRYCSAVRGEIAAPLGELLNWRPGLQYLFAKPPHG
ASMALAVFSGTAPGSGVLVWVEGRYLADMVQSAGKLGFPGIEIEVAGTRFMLNGGAGGAG
GAGGAGGAVSDAGEHAGAPALVRRDDAGQGAHGIVDIRPLTGHPITVIASAPHSLILHES
LKYMVLPPLAAGIAALMVLGLHSRRAARRSFAAELQRGLRNGEFVPYYQPVVDLESGLCT
GVEVLARWAHPRRGLLEPEHFIPAIEQQHLAVALTLHLIPRVLRDIEPLALPPAFHLAFN
VTSEHFDDAGFWAEDSPLFALLLANVTPVLEITERDAVSLVEHQRSAIQRAKARGIKLAV
DDFGTGYCGLAYFKQFEVDFLKLDRIFVQADPGDKVSGQIVDVTISFAHALDLAVVAEGI
ECEAQRAWLAGKGVRLGQGYHFARPLTRDGLCGWLPSHLERGVPAALPGDGLAVPERV