Protein Info for RR42_RS20355 in Cupriavidus basilensis FW507-4G11

Annotation: alpha-2-macroglobulin

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 200 400 600 800 1000 1200 1400 1600 1800 2006 signal peptide" amino acids 1 to 38 (38 residues), see Phobius details PF11974: bMG3" amino acids 547 to 666 (120 residues), 82.9 bits, see alignment 4.4e-27 PF01835: MG2" amino acids 673 to 777 (105 residues), 60.3 bits, see alignment 5.8e-20 PF07703: A2M_BRD" amino acids 1062 to 1245 (184 residues), 68.6 bits, see alignment E=2.2e-22 PF00207: A2M" amino acids 1305 to 1390 (86 residues), 26.9 bits, see alignment (E = 1.1e-09) PF17973: bMG10" amino acids 1866 to 1990 (125 residues), 101.9 bits, see alignment 9.7e-33

Best Hits

Predicted SEED Role

"Large extracellular alpha-helical protein"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YHW7 at UniProt or InterPro

Protein Sequence (2006 amino acids)

>RR42_RS20355 alpha-2-macroglobulin (Cupriavidus basilensis FW507-4G11)
MTQIVARMDKRERRGYWWAAAACLQAVLATMPGSGQAAQVVRFSPEGEVARVRQVAIRFD
EAMVPLGDLQASPPATVSCNGSTITGQARWIDAKNWAFDFARDLPPGVKCTVRMAPGLKS
EAGKAYAGKPEYRFETGGPTVVSARPGGGEIEEDQVFALRFNGPATAGSVRNATWCQAQG
LGERIPVRLVAGKERDAVLGALHWKLKADEVDTVHLLACQQRLPSGARMQLVLGSGVATP
SGLVTRDERRFDYTVREPFTASFTCERERAQSPCTPLRPISLSFSAPISRKDAEHILLNT
PKGPRAPQFEPQAARDAPISSVSFKPPFAEKTELTLSVPAGLKDDSGRVLSNAELFPLKV
GMAAMPPLAKFPAAPFGVLERFGELPKGKPAVDYPALLPVTLRNVEADLPAQGVRAQAGT
VRRLKVDDDGAVLRWYGLVRRLHEGSWTRGELDAILAGRSPSAVNNPRNAPSIETRSISL
LDGVAGARKLAIPQLVEPGGKAPRPFEVVGIPLPEAGFHVVEIASPMLGEALLGKPAPMY
VRTAALVTNLGVHFKLARGPGKMTALAWVTTLDDGKPVANAAVALRDCSGKLLASGRTDA
AGLASFNGLDDVRERSCDDTGLSGYFVSARIAADHPQARGQADMAFVMSDWNQGIESWRF
NVPTDTGAVPDVRVHTIFDRTLLRAGETVSMKHMIRTETANGFALPGAGDPLPEKLVIQH
EGSGQTYEQPVQWRSTATGGRSAESTFAIPAAAKLGVYTVSFSDGKDHVLDSGSFRVEAF
RLPVLAGTLKAGSGGALVAPAEVPLNLEVHYVSGGGAAGLPVQVSALLRDKYVRFADYDS
YAFTAPRKAQKDSSGDEDEGEDGNTPRDDAQKLVADKLPLKLDKNGGGTLTLKNVPRLDA
PKDLVVESGFADPNGEIQTLRQTVPMWPAGVVAGIRTESWVSVRQKLPVHAVALDPQGRP
QANVPISLRAQARITTSVRKRVVGGFYRYDNRNENKDLGIVCEGRTDAQGRMQCDVTLPE
AGQVELIAQARDNAGRVSQAATSVWVTRQGELWFGGENNDRIDLLPEKKAYAPGETAVFQ
VRMPFRHATALVAVEREGVLETSVVELNGRDPTVRVKVRPEWGPNVYVSVLALRGRLREV
PWYSFFTWGWRQPTEWWQAFRSEGREYAAPSALVDLSKPAFRLGLAEIRVGNEGYKLDVK
VTPDKTSYPVRGKAQVAVQVKLPDGRPAANGEVALAAVDEALLELMPNTSWDLLDAMLRR
RSYGVQTATAQMEIIGRRHYGRKAVPAGGGGGKSPTRELFDTLLLWNPRVQLDGEGRATL
TVPLNDSLTRFRIVAVADLGVGRFGNGSATIAATQDLQLISGLPPLVREEDRYRAMFTLR
NTTQRVMTVQAVARVSPPGQSVQPQALAAQTVEIPAGESREIGWDAAAPLLPAGSSAQDG
TVQWEVEATEAGKTGGASDRVKLSQQLVPAVPLTVQQATLAQLAPNLSVPVRAPQGALAD
GAGQPRGGLQVNLQASLAGGMPGVREWFRNYPFSCLEQRASRAIGLGDAAQWNALTTQLP
GYLDNDGLASYFPLQNDGNAGSEVLTAYLLAVSDEAVRAGLPLRLPDETRARMESGLAAF
IEGRIKRERWAPTQDLEVRKLAALEALSRSGHAQARMLGSIQILPAQWPTSALLDWIAVL
SRVQDIPQREERLAQAQQILRSRLTVQGTRLAFSTERGDNWWWLMSGGDLNAARLLALSL
DLPGWKDESAQLATGLLGRQMRGAWGTTTANAWGSLAITRFAQAFEKTPVSGATRVTLEG
VPDASRSFDWARAGKVDGVASGGISLPWPRAGESATLQAVQQGAGKPWATVRALAAVPLA
APLSAGYRITRSVTAVEQAVAGRWSRGDTYRVKLEIDAQADMTWVVVSDPVPAGATILGS
GLGRDSEIATRGERRKGAWPAFTERTPQALREYYAYMPRGSATVEYTVRLNNAGEFALPP
TRVEAMYAPDVFGAQPNARLTVGERP