Protein Info for RR42_RS18895 in Cupriavidus basilensis FW507-4G11

Annotation: imidazole glycerol phosphate synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01855: imidazole glycerol phosphate synthase, glutamine amidotransferase subunit
  • amino acids 4 to 214 (211 residues), 199.3 bits, E=3e-63
• PF00117: GATase
  • amino acids 6 to 212 (207 residues), 63.2 bits, E=1.4e-21

Best Hits

Swiss-Prot: 87% identical to HIS5_CUPNJ: Imidazole glycerol phosphate synthase subunit HisH (hisH) from Cupriavidus necator (strain JMP 134 / LMG 1197)

KEGG orthology group: K02501, glutamine amidotransferase [EC: 2.4.2.-] (inferred from 89% identity to rme:Rmet_3244)

Predicted SEED Role

"Imidazole glycerol phosphate synthase amidotransferase subunit (EC 2.4.2.-)" in subsystem Histidine Biosynthesis (EC 2.4.2.-)

MetaCyc Pathways

• superpathway of histidine, purine, and pyrimidine biosynthesis (44/46 steps found)
• L-histidine biosynthesis (10/10 steps found)

KEGG Metabolic Maps

• Biosynthesis of alkaloids derived from histidine and purine
• Biosynthesis of plant hormones
• Purine metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.4.2.-

Use Curated BLAST to search for 2.4.2.-

Sequence Analysis Tools

See A0A0C4YKP9 at UniProt or InterPro

Protein Sequence (217 amino acids)

>RR42_RS18895 imidazole glycerol phosphate synthase (Cupriavidus basilensis FW507-4G11)
MTTIAIVDYGMGNLRSVAQALRAAAPEADVQVVDQPEAIRAADRVVLPGQGAMPDCMGAL
GASGLQQAVIEAAASKPMLGVCVGEQMLFDFSKESRTQDGSTPCLGLLPGEVIRFELEGM
TQPDGSRYKVPQMGWNRVRQVRSHPLWAGIPDESWFYFVHSYYVHAQDPAHIAGETDYGV
LFTSAVARDNIFATQFHPEKSAAMGLRLYRNFVHWNP