Protein Info for RR42_RS18025 in Cupriavidus basilensis FW507-4G11

Annotation: preprotein translocase subunit SecA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 900 927 PF07517: SecA_DEAD" amino acids 6 to 405 (400 residues), 429.8 bits, see alignment E=1.3e-132 TIGR00963: preprotein translocase, SecA subunit" amino acids 28 to 827 (800 residues), 1120.8 bits, see alignment E=0 PF01043: SecA_PP_bind" amino acids 232 to 361 (130 residues), 130.8 bits, see alignment E=8.4e-42 PF21090: P-loop_SecA" amino acids 422 to 625 (204 residues), 311.3 bits, see alignment E=7.5e-97 PF07516: SecA_SW" amino acids 627 to 840 (214 residues), 230.2 bits, see alignment E=6.5e-72 PF02810: SEC-C" amino acids 907 to 925 (19 residues), 39.6 bits, see alignment (E = 9.2e-14)

Best Hits

Swiss-Prot: 75% identical to SECA_BURCH: Protein translocase subunit SecA (secA) from Burkholderia cenocepacia (strain HI2424)

KEGG orthology group: K03070, preprotein translocase subunit SecA (inferred from 75% identity to bcm:Bcenmc03_0539)

Predicted SEED Role

"Protein export cytoplasm protein SecA ATPase RNA helicase (TC 3.A.5.1.1)" (TC 3.A.5.1.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YGE9 at UniProt or InterPro

Protein Sequence (927 amino acids)

>RR42_RS18025 preprotein translocase subunit SecA (Cupriavidus basilensis FW507-4G11)
MITGLLKKVFGSRNERLIKQYGRTVAQINALEPKFEALSDDDLRGMTEIFRQRHAAGESL
EALLPEAFAVCREASKRIMKMRHFDVQLIGGMVLNDNKIAEMRTGEGKTLTATLPVYLNA
ITGRGVHVVTVNDYLAQRDAEWMGRLYNFLGLSVGVNLSQMPHDQKAAAYASDITYGTNN
EFGFDYLRDNMVYDPGQRVQRPLNYAIVDEVDSILIDEARTPLIISGQAENQTDLYQRMN
GVPKLLVRQIGEEKADGTGVEKPGDYFVDEKGHQVYLTEAGHEKAEEILMQQGLIGEGES
LYAPQNITLMHHLYAALRAQSLFHRDQHYVVQNDEVVIVDEFTGRLMTGRRWSDGLHQAV
EAKEGVTIQQENQTLATITFQNYFRMYEKLSGMTGTADTEAYEFQEIYGLEVVVIPTNRG
AQRKDFQDQIYKTSNERYDAVVRDIRDCYERGQPVLVGTTSIETSEYLSGLLDKAKLPHQ
VLNAKQHEREAEIVAQAGRPKMITIATNMAGRGTDIVLGGNVEKQAGFIEADESLSEADK
AARIAHLEGEWQSLHEQVKAAGGLHIVGTERHESRRIDNQLRGRAGRQGDPGSSRFYLSL
DDQLLRIFAGDRVRAIMERLKMPEGEPIEAGIVTRSIESAQRKVEGRNFDIRKQLLQYDD
VANDQRKEIYKLRNEVLESQDVGEMVKNLRQSVLVEMFRDHVPADTMEEQWDIKGLETKL
REEWSLDLPLAATIEAAQSIEDEVLLDKIMRAADERYDAKVNQVGRESFAGFERSVMLQS
IDTHWREHLAALDHLRQGIHLRGYAQKDPKQEYKRESFELFASLLDVIKVEVTRVIFNVQ
IQSPEELEQASEQIEEGLSHLANVQYKHEEFDEATQGAESVGSSAPERAGIAYAAAAQAA
DMAKVGRNDPCPCGSGKKFKQCHGKLS