Protein Info for RR42_RS17490 in Cupriavidus basilensis FW507-4G11

Annotation: NADP transhydrogenase subunit alpha

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF05222: AlaDh_PNT_N
  • amino acids 4 to 136 (133 residues), 139.7 bits, E=7.1e-45
• PF01262: AlaDh_PNT_C
  • amino acids 140 to 369 (230 residues), 235.9 bits, E=3.4e-74

Best Hits

KEGG orthology group: K00324, NAD(P) transhydrogenase subunit alpha [EC: 1.6.1.2] (inferred from 91% identity to reu:Reut_A2823)

Predicted SEED Role

"NAD(P) transhydrogenase alpha subunit (EC 1.6.1.2)" in subsystem Phosphate metabolism (EC 1.6.1.2)

MetaCyc Pathways

• NAD(P)/NADPH interconversion (3/6 steps found)

KEGG Metabolic Maps

• Nicotinate and nicotinamide metabolism

Isozymes

Compare fitness of predicted isozymes for: 1.6.1.2

Use Curated BLAST to search for 1.6.1.2

Sequence Analysis Tools

See A0A0C4YJQ7 at UniProt or InterPro

Protein Sequence (373 amino acids)

>RR42_RS17490 NADP transhydrogenase subunit alpha (Cupriavidus basilensis FW507-4G11)
MHIGIPQETRAGETRVAATPETVKKYVTQGHQVIVQSGAGVRASVPDSAYEAVGATIGTA
AQAFGTQLVLKVRAPVDAELALMKPGAVLVGMLNPFDAENNARMASATLTAFALEAAPRT
TRAQSMDVLSSQANIAGYKAVLVAAHHYQRFMPMLMTAAGTVKAARVLILGAGVAGLQAI
ATAKRLGAVIEASDVRPAVKEQIESLGAKFLDVPFVTDEEREIAQGVGGYARPMPPDWMR
RQAELVHERAKAADIVITTALIPGRQAPVLLKEETVQAMKPGSVVVDLAAAQGGNCPLTV
ADEVVERHGVTLIGHTNLASMVAADASALYARNVLDFLKLVIDKEGQFTLNLEDDIVAAC
LMCKDGQVVRGAS