Protein Info for RR42_RS17205 in Cupriavidus basilensis FW507-4G11

Annotation: DNA mismatch repair protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 680 TIGR00585: DNA mismatch repair protein MutL" amino acids 14 to 314 (301 residues), 305.3 bits, see alignment E=3.4e-95 PF02518: HATPase_c" amino acids 33 to 89 (57 residues), 32.1 bits, see alignment 2.8e-11 PF13589: HATPase_c_3" amino acids 36 to 135 (100 residues), 44.8 bits, see alignment E=2.6e-15 PF01119: DNA_mis_repair" amino acids 217 to 333 (117 residues), 131.4 bits, see alignment E=2.7e-42 PF08676: MutL_C" amino acids 494 to 636 (143 residues), 157.8 bits, see alignment E=3.1e-50

Best Hits

Predicted SEED Role

"DNA mismatch repair protein MutL" in subsystem DNA repair, bacterial MutL-MutS system

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y624 at UniProt or InterPro

Protein Sequence (680 amino acids)

>RR42_RS17205 DNA mismatch repair protein (Cupriavidus basilensis FW507-4G11)
MPAQAPHPAQPLRPIRPLPDQLISQIAAGEVVERPASVVKELLENALDAGATQLNLRLEE
GGVRRIVIADNGCGIPADELPVALKRHATSKIASLDELEAVLTLGFRGEALASIASVSEL
TLTSRTASDTHAMQVIADTGVVQPASGGVGTTVDVQHLYFNTPARRKFLKSEQTEFGHCL
EMVRRAALARPDVAISVHHNGKPMEHWNAGDVATRTAQVLGTDFANARLPLDEEAGSLHL
YGFAGLPTASRGRPDQQFFFVNGRYVRDKLLTHAVRSAYQDVLHGDRFPSYVLCMDLPPE
MVDVNVHPSKIEVRFRESRSVHQFVYHAVQRCLARQAGEQGDSLHTSVDSNNPAAAEPIG
GAGGFPGARSFGGGSGGSGGFAGSGRSGGMGGGMGGGASPRPWVDYTAAARQTELGVAQP
RQAYLGMVRDAIQPGGGFSRGPSAYVPPDGPGTTPPAWLADAQAARENDPPGLLDQLARQ
ELPEDEASPLGYAIAQLHGIYVLAQNARGLVLVDMHAAHERILYEQIKTALEARELAVQS
LLIPVTLTASPVEIGTAEEHQETLTLLGFDIAQVSPTTLAIRAIPALLKQADTEALARDV
LRDLQAFGGSRVLVERQNELLATLACHSAVRANRKLTLEEMNALLRQMEQTERADQCNHG
RPTWVQLTVAELDRLFLRGQ