Protein Info for RR42_RS16505 in Cupriavidus basilensis FW507-4G11

Annotation: adenylate cyclase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 551 signal peptide" amino acids 1 to 25 (25 residues), see Phobius details transmembrane" amino acids 44 to 69 (26 residues), see Phobius details amino acids 81 to 99 (19 residues), see Phobius details amino acids 131 to 151 (21 residues), see Phobius details amino acids 163 to 181 (19 residues), see Phobius details amino acids 221 to 238 (18 residues), see Phobius details PF00111: Fer2" amino acids 262 to 331 (70 residues), 27.1 bits, see alignment E=3.3e-10 PF00211: Guanylate_cyc" amino acids 363 to 513 (151 residues), 48.5 bits, see alignment E=8.5e-17

Best Hits

KEGG orthology group: K01768, adenylate cyclase [EC: 4.6.1.1] (inferred from 48% identity to bra:BRADO1430)

Predicted SEED Role

"Adenylate cyclase (EC 4.6.1.1)" in subsystem cAMP signaling in bacteria (EC 4.6.1.1)

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 4.6.1.1

Use Curated BLAST to search for 4.6.1.1

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YJ79 at UniProt or InterPro

Protein Sequence (551 amino acids)

>RR42_RS16505 adenylate cyclase (Cupriavidus basilensis FW507-4G11)
MRSVRLTTGLVLFTYVGTHLLNHSLGNISLAWLERGLLVQKFIWQGWLGTALLYSALVAH
FFLGLWALYERRSLHWTPGEVAQLVLGLCIPPLLVNHVVNTRVAFAEFGLNKSYAQLLYA
FWIDSPFFGRVQLMLLVVAWLHGCYGIWFWLRLKPWFGAWRSVLLSVAVLVPVLALLGFL
QGGREVIALAQDPVWRAAATRTTIIGTGLQNLWLAELRNDFLLFDGGALLLVLAARLVRT
VRERRAGRLCVQYPDGRKVFAPLGFSVLEASRMAGVPHASTCGGRARCTLCRVRVLSAVP
LPAPAEAERRVLERLGADSRTVRLACQLRPTHDLRVWPLVPPAASAAFLQRRQRDVMPQE
RFAAFMFVDMRDSTKLAAAQLPYDSLFMVSRFLSAVCAAVVQAGGLPNQFLGDAVLAIFG
LRCEPAEACRQALGAVPLVAANIEELNAALKQQLHTPIRFGIGLHCGRAVMGEIGFRDHV
TFTAIGDPLNVASRLEQLTKEMACEAIVSEQVFQQAGVSAAGLPQLAAHLRGRDDPVPVC
VLTKAAQMPRA