Protein Info for RR42_RS16240 in Cupriavidus basilensis FW507-4G11
Annotation: cobalamin biosynthesis protein CbiX
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K03795, sirohydrochlorin cobaltochelatase [EC: 4.99.1.3] (inferred from 73% identity to reu:Reut_A2686)Predicted SEED Role
"Sirohydrochlorin cobaltochelatase (EC 4.99.1.3)" in subsystem Coenzyme B12 biosynthesis or Experimental tye (EC 4.99.1.3)
MetaCyc Pathways
- siroheme biosynthesis (3/4 steps found)
- factor 430 biosynthesis (3/7 steps found)
- adenosylcobalamin biosynthesis I (anaerobic) (22/36 steps found)
- cob(II)yrinate a,c-diamide biosynthesis I (early cobalt insertion) (6/15 steps found)
KEGG Metabolic Maps
Isozymes
No predicted isozymesUse Curated BLAST to search for 4.99.1.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0C4Y5M0 at UniProt or InterPro
Protein Sequence (134 amino acids)
>RR42_RS16240 cobalamin biosynthesis protein CbiX (Cupriavidus basilensis FW507-4G11) MNTTPLPRQAMVLFGHGARDARWREPFDRLHARLTAALPDCAVRLAFLELMTPSLPDTLA ELAAGGVTDINVVPVFFGQGGHLRRDLPALLDDCRSQLAGVTIRCAAAVGEDDSVLDAIA AYCVVTLAGAEQRT