Protein Info for RR42_RS15855 in Cupriavidus basilensis FW507-4G11

Annotation: dihydroorotase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 424 TIGR00857: dihydroorotase, multifunctional complex type" amino acids 19 to 422 (404 residues), 321.7 bits, see alignment E=3.6e-100 PF01979: Amidohydro_1" amino acids 260 to 420 (161 residues), 37.2 bits, see alignment E=2.1e-13 PF07969: Amidohydro_3" amino acids 283 to 421 (139 residues), 39.2 bits, see alignment E=6.4e-14

Best Hits

Swiss-Prot: 42% identical to PYRC_GEOSM: Dihydroorotase (pyrC) from Geobacter sp. (strain M21)

KEGG orthology group: K01465, dihydroorotase [EC: 3.5.2.3] (inferred from 91% identity to cti:RALTA_A2393)

Predicted SEED Role

"Dihydroorotase (EC 3.5.2.3)" in subsystem De Novo Pyrimidine Synthesis (EC 3.5.2.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 3.5.2.3

Use Curated BLAST to search for 3.5.2.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YCH9 at UniProt or InterPro

Protein Sequence (424 amino acids)

>RR42_RS15855 dihydroorotase (Cupriavidus basilensis FW507-4G11)
MKIHIKGGRLIDPAANVDAQQDLYIAAGKIVGVGSAPADFHANKTIDASGLIVCPGLVDL
SARLREPGYEYKATLESEVAAATAGGVTSLVCPPDTDPVLDEPGLVEMLKYRARTLNQTH
VYPLGALTLGLKGETLTEMSQLTEAGCIGFSQAEAPIRNTQVLLRALQYAQTFGFTVWLR
PEDPYLGGGVAASGAVASRLGLSGMSVIAETVRLHTIFELMRASGARVHLCRLSSAAGIE
LVRQAKREGLKVTCDVNIHHVSLTDMDIGYFNSQMRFSPPLRSARDRDAIVAGLADGTID
ALCSDHTPVDDDEKLLPFAEASPGATGLELLLPLTLRWAEEHKVPLGKALARITAEPASV
LGLAAGTLATGSAADICIFHPEQEWKVERRALKSQGKNSPWLGYEMRGRVRTTLVGGHVV
YELH