Protein Info for RR42_RS15445 in Cupriavidus basilensis FW507-4G11

Annotation: 7-cyano-7-deazaguanine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 227 signal peptide" amino acids 1 to 23 (23 residues), see Phobius details PF06508: QueC" amino acids 4 to 215 (212 residues), 252.1 bits, see alignment E=3.8e-79 TIGR00364: queuosine biosynthesis protein QueC" amino acids 5 to 208 (204 residues), 196.5 bits, see alignment E=1.9e-62 PF00733: Asn_synthase" amino acids 7 to 62 (56 residues), 36.4 bits, see alignment E=5.1e-13

Best Hits

Swiss-Prot: 93% identical to QUEC_CUPTR: 7-cyano-7-deazaguanine synthase (queC) from Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1)

KEGG orthology group: K06920, queuosine biosynthesis protein QueC (inferred from 93% identity to cti:RALTA_A2314)

Predicted SEED Role

"Queuosine Biosynthesis QueC ATPase" in subsystem Queuosine-Archaeosine Biosynthesis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YC63 at UniProt or InterPro

Protein Sequence (227 amino acids)

>RR42_RS15445 7-cyano-7-deazaguanine synthase (Cupriavidus basilensis FW507-4G11)
MKKRAIVLLSGGLDSATVLAMANAQGFETYALSMRYGQRHSSELEAAKRVAAALGAVRHE
IIDLDLRRFGGSALTDDSLEVPTDGAVGGIPVTYVPARNTIMLSLALGWAEAVGGRDLFF
GANAVDYSGYPDCRPEYVSAYEALANLATKAGVEGERIRVHAPIIDMTKGEIIRAGVKLG
VDYGMTVSCYKADDDGRACGVCDSCRIRRAGFEAAGVPDPTRYQGAA