Protein Info for RR42_RS14555 in Cupriavidus basilensis FW507-4G11

Annotation: heat-shock protein Hsp90

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 637 PF13589: HATPase_c_3" amino acids 30 to 156 (127 residues), 36.5 bits, see alignment E=7e-13 PF02518: HATPase_c" amino acids 31 to 183 (153 residues), 26.8 bits, see alignment E=9.1e-10 PF00183: HSP90" amino acids 222 to 636 (415 residues), 425 bits, see alignment E=8.4e-131

Best Hits

Swiss-Prot: 91% identical to HTPG_CUPTR: Chaperone protein HtpG (htpG) from Cupriavidus taiwanensis (strain DSM 17343 / BCRC 17206 / CIP 107171 / LMG 19424 / R1)

KEGG orthology group: K04079, molecular chaperone HtpG (inferred from 91% identity to cti:RALTA_A2146)

MetaCyc: 62% identical to chaperone protein HtpG (Escherichia coli K-12 substr. MG1655)
Non-chaperonin molecular chaperone ATPase. [EC: 3.6.4.10, 5.6.1.7]

Predicted SEED Role

"Chaperone protein HtpG" in subsystem Protein chaperones

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.6.4.10 or 5.6.1.7

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YBN4 at UniProt or InterPro

Protein Sequence (637 amino acids)

>RR42_RS14555 heat-shock protein Hsp90 (Cupriavidus basilensis FW507-4G11)
MTAPHETMSFQAEVKQLLHLMIHSLYSNKEIFLRELVSNASDATDKLRFEAIANPALLEN
DADLAIRIEADAKARTLKITDNGIGMSRDEAIRNLGTIARSGTKEFFQQLSGDQQKDAAL
IGQFGVGFYSAFIVADKVTVETRRAGLPASEAVRWESAGDGEFTVDAIDRAERGSTITLH
LREGEDDFLSAWKIKGIIQKYSDHISLPIRMPKEVWDAETSAYKETGEWESVNQASALWT
RSKSDITEEQYTAFYQHIAHDNEAPLAYTHNRVEGRSEYTQLLYVPARAPFDMWDRNHKA
GLKLYVKRVFIMDDAEQLLPAYLRFVKGVVDSADLPLNVSRELLQESRDVKAIREGCTKR
VLSMLETLADSEDEAERAKYTTFWQQFGQALKEGLGEDAANLERIAKLVRFASTHQDSAE
QSVALAAYVGRMKEGQDKIYYVTADSWAAAKSSPHLEVFRKKGIEVLLLTDRVDEWMLSF
LREFDGKELVSVARGDLELGALADADEKAEQEKAEGDWKDVLERAKAVLEGKAKDVRVTL
RLTESASCLVSDEGDMSGYLQRLLKQAGQKAPDAQPILELNPDHALVKKLRALVEAGPTD
DAFGDRVHVLFDQALLAEGGTLEDPSIYVQRVNKLLA