Protein Info for RR42_RS13920 in Cupriavidus basilensis FW507-4G11

Annotation: energy transducer TonB

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 218 transmembrane" amino acids 6 to 23 (18 residues), see Phobius details signal peptide" amino acids 24 to 26 (3 residues), see Phobius details PF03544: TonB_C" amino acids 139 to 217 (79 residues), 74.7 bits, see alignment E=6.6e-25 TIGR01352: TonB family C-terminal domain" amino acids 141 to 218 (78 residues), 60.3 bits, see alignment E=9.1e-21 PF13103: TonB_2" amino acids 150 to 200 (51 residues), 29 bits, see alignment E=9.6e-11

Best Hits

KEGG orthology group: K03832, periplasmic protein TonB (inferred from 85% identity to reh:H16_A2532)

Predicted SEED Role

"Ferric siderophore transport system, periplasmic binding protein TonB" in subsystem Campylobacter Iron Metabolism or Hemin transport system or Ton and Tol transport systems

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YDR0 at UniProt or InterPro

Protein Sequence (218 amino acids)

>RR42_RS13920 energy transducer TonB (Cupriavidus basilensis FW507-4G11)
MFDQRFFKITLAVLLFHVGLLYLIQSGLGRKITEAVISPEVVARIIPLEPPQKPAVETPK
PKPETPPKQVKVTAPKPAPPQPRPTPTPVASLPPTPNAVEAPLAPPAPPAPPAPAPEPAA
PVSAAPRAVGIGEIQCSPPQPTYPSQSRRMGETGKAVVRLTTDDTGKVVKTTVVTSSGSS
RLDQAAEEAVRRMRCKPYLDNGRAVAVTAQQPIGFELN