Protein Info for RR42_RS13875 in Cupriavidus basilensis FW507-4G11

Annotation: sodium:solute symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 683 transmembrane" amino acids 12 to 33 (22 residues), see Phobius details amino acids 41 to 62 (22 residues), see Phobius details amino acids 83 to 105 (23 residues), see Phobius details amino acids 111 to 132 (22 residues), see Phobius details amino acids 159 to 179 (21 residues), see Phobius details amino acids 189 to 212 (24 residues), see Phobius details amino acids 223 to 241 (19 residues), see Phobius details amino acids 378 to 401 (24 residues), see Phobius details amino acids 413 to 434 (22 residues), see Phobius details amino acids 500 to 529 (30 residues), see Phobius details amino acids 549 to 567 (19 residues), see Phobius details amino acids 573 to 597 (25 residues), see Phobius details amino acids 604 to 625 (22 residues), see Phobius details amino acids 645 to 666 (22 residues), see Phobius details TIGR03648: probable sodium:solute symporter, VC_2705 subfamily" amino acids 45 to 681 (637 residues), 708.1 bits, see alignment E=3.4e-217 PF00474: SSF" amino acids 70 to 237 (168 residues), 109 bits, see alignment E=1.4e-35 amino acids 498 to 613 (116 residues), 64.7 bits, see alignment E=3.8e-22

Best Hits

Swiss-Prot: 91% identical to Y2524_CUPNH: Uncharacterized symporter H16_A2524 (H16_A2524) from Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337)

KEGG orthology group: K14393, cation/acetate symporter (inferred from 91% identity to reh:H16_A2524)

Predicted SEED Role

"Acetate permease ActP (cation/acetate symporter)" in subsystem Pyruvate metabolism II: acetyl-CoA, acetogenesis from pyruvate

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YBH0 at UniProt or InterPro

Protein Sequence (683 amino acids)

>RR42_RS13875 sodium:solute symporter (Cupriavidus basilensis FW507-4G11)
MPDEQSRFRRRLLLYYGLFTIGLFVFIGMMGLLEHSSGDALWLGYVFLFVTIAIYACIGL
ICRTSDLNEYYVAGRRVPALFNGMAIAADWMSAASFIGLAGILFASGYEGLAYVMGWTGG
YCLVAFLLAPYLRKYGGYTIPDFLAARYGNGKPGGNMPVRAIAVMAASLCSFVYLVAQIQ
GVGLIVTRFIGVEFAVGVFFGLAGILVCSFLGGMRAVTWTQVAQYIMLIAAFLVTVSMIA
WKHHHEALPQLSYGTLLQQLDTRERSIERDPAEQAVREYYRQQAIQMQDRISRLPQSFDE
ERNALSARLQELRLRNAPLREIKTVERERVEFPRDIAAAQQQWNQQREEALARSQPSTPS
TEPYPSPSEAERKTKRLNFVLLVFCLMLGTASLPHILTRLYTTPSVKESRNSVAWAVFFI
ALLYVSAPALAALVKYEFFQHLVGTPYAELPQWVVQWRKVDPPVFGIRDVNGDGIVQWAE
ILIQPDMIVLAAPEIAGLPYVISGLVAAGALAAALSTADGLLLTIANALSHDVFYHMGDR
TASHQRRVTTAKIVLLGVALFASYVTSLRPGNILFLVGAAFSLAASSFFPVLVLAIFWRR
TTAAGAVAGMVAGLGVAVYYIFVNYPFFTRMTGIFGNRWFGVDPIASGAFGVPAGFAVAI
LVSLLTPRNAPVIDRLVTYLRRG