Protein Info for RR42_RS11445 in Cupriavidus basilensis FW507-4G11

Annotation: Fis family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 679 PF01590: GAF" amino acids 77 to 205 (129 residues), 50 bits, see alignment E=1.3e-16 PF00158: Sigma54_activat" amino acids 351 to 513 (163 residues), 223.2 bits, see alignment E=5e-70 PF14532: Sigma54_activ_2" amino acids 353 to 519 (167 residues), 64.4 bits, see alignment E=4e-21 PF02954: HTH_8" amino acids 631 to 670 (40 residues), 46 bits, see alignment 1.1e-15

Best Hits

KEGG orthology group: None (inferred from 80% identity to reh:H16_B1055)

Predicted SEED Role

"Nitrogen regulation protein NR(I)" in subsystem Ammonia assimilation

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y3E5 at UniProt or InterPro

Protein Sequence (679 amino acids)

>RR42_RS11445 Fis family transcriptional regulator (Cupriavidus basilensis FW507-4G11)
MTFQAAAGPHVPGVSPAVTGNPAEGDRPDLIAQAHQRSESYGLRPYESPDFCPVLQNELK
TQIERSQSLFTYALPVMETLYDQIVNTQSMVILTDAAGLILHSLGDDDFLAKASKVALQP
GALWSEESRGTNAIGTALAENKATLVHGAEHFLEANRFLTCSCMPILDAYGKTVGALDVT
GDQRGFHKHTMALVRMSAQMIENQLFANAFQDMVCVRFHSRAEFIGTLVEGIASFTPGGR
FLSANRSAQFQLGMSVAALHAHTFSSLFGQSLSQLFDAERKAPGGVVYLPLPSGVKVSAR
IEWKAPAASVPAVAIDRGSAQAQSRPEATCLPHRAATQPTQPGLDDLDTGDAQIQGVITK
LRKVIGKDIPVMVLGETGTGKELLARAIHADSPRHAGPFIAVNCASIPETLIESELFGYE
EGAFTGARKKGGIGKMLLANGGTLFLDEIGDMPLHLQARMLRALQERAVTPLGSSKVIHV
DVSVICATNRNMREQVANGLFREDLYYRLNGLVVRLPALRERSDLDVVANKLLREGQASG
GPRIKDSVMAMFRSYHWPGNIRQLGNLLRTARLMAEGEAEITEDHLPDDFLEDRLARQAT
HPAHGATVAPDAAPDGERAAGAAPRAQPTRLADVEALAIVAAVKAHHGNISAAAKALGIS
RNTVYRKLDEANALPQQDG