Protein Info for RR42_RS09140 in Cupriavidus basilensis FW507-4G11

Annotation: phosphoribosylformylglycinamidine synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1200 1348 signal peptide" amino acids 1 to 18 (18 residues), see Phobius details TIGR01735: phosphoribosylformylglycinamidine synthase" amino acids 8 to 1347 (1340 residues), 1866.7 bits, see alignment E=0 PF18076: FGAR-AT_N" amino acids 38 to 159 (122 residues), 126.9 bits, see alignment E=7.6e-41 PF18072: FGAR-AT_linker" amino acids 179 to 228 (50 residues), 85.3 bits, see alignment (E = 6.6e-28) PF02769: AIRS_C" amino acids 454 to 611 (158 residues), 108.5 bits, see alignment E=7.6e-35 amino acids 859 to 1018 (160 residues), 54.3 bits, see alignment E=3.7e-18 PF13507: GATase_5" amino acids 1092 to 1347 (256 residues), 353.9 bits, see alignment E=8.4e-110

Best Hits

Predicted SEED Role

"Phosphoribosylformylglycinamidine synthase, synthetase subunit (EC 6.3.5.3) / Phosphoribosylformylglycinamidine synthase, glutamine amidotransferase subunit (EC 6.3.5.3)" in subsystem De Novo Purine Biosynthesis (EC 6.3.5.3)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 6.3.5.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YEK9 at UniProt or InterPro

Protein Sequence (1348 amino acids)

>RR42_RS09140 phosphoribosylformylglycinamidine synthase (Cupriavidus basilensis FW507-4G11)
MAHFSCFPGALALSAFRQQRLLTALKQIDADIESVHGQFLHFVDTDVPLSQDDSARIAAL
LTYGAPFEAQTDGDRFVVIPRFGTISPWASKATDIAHNCGFEHVHRIERGIEITVICKKG
LLRGRKTLDAGTRAAVAAHLFDRMTESVVASREDAAGLFQELPAKPLRFIDISGGRAALA
QANTEMGLALSEDEIDYLVDAYAKLDRNPTDVELMMFAQANSEHCRHKIFNATWTIDGVQ
QDKSLFAMIRNTHQLNPQGSIVAYSDNSAVMEGDVAERWFPRGAEQKYGRHEALTHTLMK
VETHNHPTAISPFPGASTGAGGEIRDEGATGRGGKPKAGLTGFTVSNLMLPDAVQGWENA
RDAAQPVAHRNPDDKVSVTGKPDRIASPLQIMTEGPLGGAAFNNEFGRAILGGYFRVYEQ
NVGGTVRGYHKPIMIAGGIGNIDAGHTHKKALPAGSLLIQLGGPGMRIGMGGSAASSMAT
GTNTADLDFDSVQRGNPEMERRAQEVINACWQLGDDNPILSIHDVGAGGISNAFPELVDG
AGRGARFDLRQVHLEESGMSPAEIWCNESQERYVMAVAPESFPLFQTMCQRERSPFAVVG
IATEEQQLQLVDAHVDAALKEHYAVNMPMDVLLGKPPRMHRDVRHVEQSLPPVDVTGIAL
DQAVRDVLRHPTVASKSFLITIGDRTVGGMNARDQMVGPWQVPVADVAVTTLDYKGRAGE
AMTMGERTPLAVINAPASGRMAIGEALTNLAAAPVKDLGKVKLSANWMAACGVDGEDAKL
YDTVHAVGMELCPALGISIPVGKDSLSMRTKWQDDGVDKEVVAPVSLIISAFAAVDDTDR
TLTPQLRTDAGDSVLIAIDLGRGKNRLGGSILAQVTQQVGDTTPDVDSAEDLKNFFNVIQ
RLNREGKLLAYHDRSDGGFMAALAEMAFAGHCGLSLNVDMLALDPVQEQDFGDAKNWAQQ
ISGRRDEQTLRALFSEELGAVIQVRQEERDGVFAVLREVGLSACSHVVGKPNATDQIEIY
RDAKKVFGAARSELQRTWSEVSWRIARLRDNPACADSEYDRVLDAADPGISPVLTFDPAQ
DIAAPFVATGARPRVAILREQGVNSQIEMAYSMDRAGFDTHDVHMSDLIAGRANLADFSG
FVACGGFSYGDVLGAGEGWAKTILFNAQMAEQFAAFFNRQDTFALGVCNGCQMMSNLAPI
IPGAGAWPKFTRNQSEQYEARYVTVEVQSSPSIFFAGMEGSRIPIVVAHGEGFADFSQQG
DKSQAQVALRFVDNHGAPTQTYPLNPNGSPDGITSVTTTDGRFTVLMPHPERVFRTATMS
WAPDAWKQVEDGGSPWMRMFRNARKWVG