Protein Info for RR42_RS09105 in Cupriavidus basilensis FW507-4G11

Annotation: 5-oxoprolinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 100 200 300 400 500 600 700 800 900 1000 1100 1216 PF05378: Hydant_A_N" amino acids 20 to 198 (179 residues), 192.9 bits, see alignment E=8.3e-61 PF01968: Hydantoinase_A" amino acids 218 to 509 (292 residues), 343.7 bits, see alignment E=1.7e-106 PF19278: Hydant_A_C" amino acids 522 to 687 (166 residues), 35.2 bits, see alignment E=1.8e-12 PF02538: Hydantoinase_B" amino acids 709 to 1215 (507 residues), 675.1 bits, see alignment E=1.2e-206

Best Hits

KEGG orthology group: K01469, 5-oxoprolinase (ATP-hydrolysing) [EC: 3.5.2.9] (inferred from 74% identity to bcj:BCAM0578)

Predicted SEED Role

"5-oxoprolinase (EC 3.5.2.9)" in subsystem Glutathione: Biosynthesis and gamma-glutamyl cycle (EC 3.5.2.9)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.5.2.9

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YAE9 at UniProt or InterPro

Protein Sequence (1216 amino acids)

>RR42_RS09105 5-oxoprolinase (Cupriavidus basilensis FW507-4G11)
MPQSLPSSAAVVSDRRRWQFWIDRGGTFTDVVGLQPDGTVVTHKLLSENPEQYSDAAVAG
IRHLLGLAPGEPVTPAQVEVVKMGTTVATNALLERKGEPVALFITRGFRDALRIAYQNRP
RLFDLSIVLPELLYREVVEVGERLDAQGETVMPLDQAALRADMQRVFDSGIRAIAIVFLH
GYRQAAHEQAAARIARETGFTQISVSHQVSPLMKLVSRGDTTVVDAYLSPILRRYVGQVE
QQMPGVRLQFMQSSGGLTDAHRFQGKDAILSGPAGGIVGMVRSSHSAGFGRIIGFDMGGT
STDVSHFNGDHPNDFERVFETSVAGVRMRAPMMSIHTVAAGGGSILHFDGSRFRVGPDSA
GANPGPASYRRGGPLAVTDCNVMLGKIQPRHFPAVFGPRADAALDRDTVVARFAALAQEV
TQATGDQRSAEQVAEGFIEIAVGNMANAIKQISVQRGHDVTGYTLTTFGGAGGQHACLVA
DALGMQTVFVHPLAGVLSAYGMGLADRTAMRERAVETRLDDSALPALQATLDALASEARQ
ELLEQEVAEAQIDVVRRAHLRYEGTDSALVVPFGTLPAMRAAFDAAYRQRYAFLMQGKPL
VVEALSVEAIGSSEPPEEKLPDAQPRCGGPVPAELVRMFSGGAWHDTGLFPRDTLRPGDV
LPGPAIIAERNATTVVEPGWQAELTARDHLVLTRAVPRPQRRAMGTDADPVMLEVFNNLF
MSIAEQMGQRLQNTAYSVNIKERLDFSCAIFDAGGNLIANAPHMPVHLGSMGESIKTVIA
RNAGHMADGDVYVLNDPYNGGTHLPDVTVITPVFDEAGAQILFYVGSRGHHADIGGITPG
SMPPDSTVVEEEGVMIDNFALVKAGVLDDAGMRALLAGARYPARNIDQNMADLRAQVAAN
AKGVEELRKMVVQFGLPVVRAYMGHVQDNAEEAVRRVITALKDGAYRYPLDNGAQIQVRV
SVDQARREAVVDFTGTSAQLPNNFNAPRAVCMAAVLYVFRTLVSEDIPLNAGCLKPINVI
IPEGSMLNPRYPASVVSGNVETSSCITNALYGALGVVAASQGTMNNFTFGNARYQYYETI
SGGSGAGQGFNGCDVVQTNMTNSRLTDPEVLEWRFPVRLESYEIRPGSGGAGQWHGGNGG
IRKVRFLEPMTASILSNNRLHAPFGMAGGEPGAMGRNYVVRGDGSEQALGHVGRCEMKAG
DVFVVETPGGGGYGKV