Protein Info for RR42_RS07875 in Cupriavidus basilensis FW507-4G11

Annotation: citrate-proton symporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 433 transmembrane" amino acids 21 to 43 (23 residues), see Phobius details amino acids 49 to 76 (28 residues), see Phobius details amino acids 86 to 109 (24 residues), see Phobius details amino acids 115 to 116 (2 residues), see Phobius details amino acids 119 to 140 (22 residues), see Phobius details amino acids 152 to 177 (26 residues), see Phobius details amino acids 185 to 205 (21 residues), see Phobius details amino acids 235 to 254 (20 residues), see Phobius details amino acids 274 to 293 (20 residues), see Phobius details amino acids 303 to 324 (22 residues), see Phobius details amino acids 336 to 356 (21 residues), see Phobius details amino acids 368 to 389 (22 residues), see Phobius details amino acids 399 to 417 (19 residues), see Phobius details PF00083: Sugar_tr" amino acids 17 to 417 (401 residues), 108.5 bits, see alignment E=3.9e-35 PF07690: MFS_1" amino acids 19 to 372 (354 residues), 112.4 bits, see alignment E=2.3e-36 amino acids 276 to 426 (151 residues), 33.5 bits, see alignment E=2.2e-12

Best Hits

Swiss-Prot: 63% identical to CITA_ECOLX: Citrate-proton symporter (citA) from Escherichia coli

KEGG orthology group: None (inferred from 90% identity to reu:Reut_A1366)

MetaCyc: 64% identical to propane-1,2,3-tricarboxylate-proton symporter (Salmonella enterica enterica serovar Typhimurium str. LT2)
RXN1R65-49

Predicted SEED Role

"Permeases of the major facilitator superfamily"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YDZ3 at UniProt or InterPro

Protein Sequence (433 amino acids)

>RR42_RS07875 citrate-proton symporter (Cupriavidus basilensis FW507-4G11)
MSSSPSQQHGFRTVFRVVSGNFLEMYDFMVYGFYAAAIAKTFFPSGNEFASLMLSLATFG
AGFLMRPLGAIILGAYIDHHGRRKGLIMTLVLMALGTLLIACVPGYASIGVAAPLLVLAG
RLLQGFSAGVELGGVSVYLAEIAKPGKKGFYVAWQSASQQVAVIFAGLLGVVLHSMLSPE
EMGEWGWRIPFLIGCLIVPFLFLIRRSLEETEEFKTRKHRPSISEIYRSMMENWRIIVAG
CMMVVMTTVSFYMITAYTPTFGKTVLKLDDVDNLIVTMCVGLSNFIWLPLMGALSDRVGR
KPLLVIFTILTLLTAYPAVSWLVAEPSFGRLLMVELWLSFLYGSYNGAMVVTLTEVMPPA
VRTAGFSLAYSLATALFGGFTPAISTYLIHSTGNKAAPGLWLMFAAACGLIATLVIFRGG
RQHAYVEPAAKTA