Protein Info for RR42_RS06585 in Cupriavidus basilensis FW507-4G11

Annotation: GTP pyrophosphokinase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 740 PF13328: HD_4" amino acids 23 to 188 (166 residues), 163.2 bits, see alignment E=1e-51 TIGR00691: RelA/SpoT family protein" amino acids 51 to 739 (689 residues), 584.5 bits, see alignment E=1.5e-179 PF04607: RelA_SpoT" amino acids 247 to 356 (110 residues), 150.1 bits, see alignment E=7.1e-48 PF02824: TGS" amino acids 411 to 469 (59 residues), 71.7 bits, see alignment 1e-23 PF13291: ACT_4" amino acids 664 to 739 (76 residues), 61.7 bits, see alignment E=2.2e-20

Best Hits

KEGG orthology group: K00951, GTP pyrophosphokinase [EC: 2.7.6.5] (inferred from 89% identity to reu:Reut_A1274)

Predicted SEED Role

"GTP pyrophosphokinase (EC 2.7.6.5), (p)ppGpp synthetase I" in subsystem Stringent Response, (p)ppGpp metabolism (EC 2.7.6.5)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

Compare fitness of predicted isozymes for: 2.7.6.5

Use Curated BLAST to search for 2.7.6.5

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y973 at UniProt or InterPro

Protein Sequence (740 amino acids)

>RR42_RS06585 GTP pyrophosphokinase (Cupriavidus basilensis FW507-4G11)
MVTSTDLTGQIAGTPDAGLVERALAFVRERGSAALLPTGETVLSHAEGMLRILDGLRVDD
AARAAACLFALAAFVPGSEAEIEPLFGEEVAGLVKGVRQLLRIGAIAVGHSGAPETTKDE
IAARQEQVEALRKMLLAFAQDIRVVLVRLASRLQTLRWLAQVKAQPLPGVARETLDIYAP
LANRLGIWQMKWELEDLAFRFEQPDTYKRIARLLDEKRIEREGYIASAIARLQSELASAG
IRAEVSGRPKHIYSIWKKMRGKELDFADLYDVRAFRVIVDDIKDCYTVLGIVHHIWQPIP
REFDDYISRPKSNGYKSLHTVVIGDDGRAFEVQIRTQEMHHFAEYGVAAHWRYKEAGSKG
YSGQFSASERYDEKIAWLRQLLAWKDDADHSVAHDESPWEQLKHAAIDDHIYVLTPQARV
VALPQGATPVDFAYYLHTDLGHRCRGARVDGTMVPLNTPLKNGQTVDIIAVKQGGPSRDW
LNAELGYLASPRARAKVRAWFNALDSQETMSQGRALIDKTLQREGKTAVNLDDLAARLGF
KTPDDLFAAVAKDEFSLRHVEQALRHPEGEAVVVQSEEEAVTKKSRATSVARGAKSGVLV
VGVDSLLTQMSKCCKPAPPDEIVGFVTRGRGVSIHRRTCHTFGQLSARAPERVIHTEWGK
RSDAVYPVDIHVEAIDRQGLLRDISEVLSREKINVTGVKTLSSKGVARMQFTAEVSEATQ
LQRALGLIEDVAGVLQAKRK