Protein Info for RR42_RS06260 in Cupriavidus basilensis FW507-4G11

Annotation: MBL fold metallo-hydrolase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 262 signal peptide" amino acids 1 to 16 (16 residues), see Phobius details PF00753: Lactamase_B" amino acids 12 to 90 (79 residues), 53.3 bits, see alignment E=3.7e-18 PF12706: Lactamase_B_2" amino acids 27 to 220 (194 residues), 62.3 bits, see alignment E=5.1e-21

Best Hits

KEGG orthology group: None (inferred from 86% identity to reh:H16_A1206)

Predicted SEED Role

"Metal-dependent hydrolases of the beta-lactamase superfamily I" in subsystem Beta-lactamase

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y722 at UniProt or InterPro

Protein Sequence (262 amino acids)

>RR42_RS06260 MBL fold metallo-hydrolase (Cupriavidus basilensis FW507-4G11)
MMRFAFLGSGSEGNSLLIESQEGTTTTRVLLDCGFGIRETARRLERLGITPDQLDAVLVT
HEHGDHVGSAYAFASRHDLPVHTSHGTWLATSHMRGADKADVRVCGADHPLVIGGLHILP
YTVPHDAREPLQFVLSDGDARLGVLTDAGMETPYVTARLAGVHALVLECNHDREMLRNSA
YPYSLKQRIGGDFGHLANEVAAGILERVAHAGLQRVVAAHLSQQNNTRELATQALASVLG
VSSGDILVADQHEGLGWQPVRA