Protein Info for RR42_RS05940 in Cupriavidus basilensis FW507-4G11

Annotation: co-chaperone GrpE

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 185 PF01025: GrpE" amino acids 31 to 182 (152 residues), 164.7 bits, see alignment E=7.9e-53

Best Hits

Swiss-Prot: 83% identical to GRPE_CUPNJ: Protein GrpE (grpE) from Cupriavidus necator (strain JMP 134 / LMG 1197)

KEGG orthology group: K03687, molecular chaperone GrpE (inferred from 83% identity to reh:H16_A1137)

Predicted SEED Role

"Heat shock protein GrpE" in subsystem Heat shock dnaK gene cluster extended or Protein chaperones

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y6V8 at UniProt or InterPro

Protein Sequence (185 amino acids)

>RR42_RS05940 co-chaperone GrpE (Cupriavidus basilensis FW507-4G11)
MEEQKQTPSTTPPLTPASEELNTAPAGQADNAATVDVAAQLAALEAKAKENYDMFLRATA
EGENIRRRAQEDVAKAHKFAIETFADYLLPVMDSLQAALADGSGDIAKLREGVELTARQL
VSAFEKGKIVELNPVGEKFDPHRHQAISMVPAPQEPNTVVTVLQRGYTIADRVLRPALVT
VSAPK