Protein Info for RR42_RS05745 in Cupriavidus basilensis FW507-4G11

Annotation: aminoglycoside phosphotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 358 transmembrane" amino acids 304 to 321 (18 residues), see Phobius details PF01636: APH" amino acids 42 to 272 (231 residues), 180.2 bits, see alignment E=6e-57 PF02958: EcKL" amino acids 174 to 256 (83 residues), 22.5 bits, see alignment E=6.8e-09

Best Hits

KEGG orthology group: K06979, (no description) (inferred from 92% identity to cti:RALTA_A1084)

Predicted SEED Role

"Predicted aminoglycoside phosphotransferase"

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y8S9 at UniProt or InterPro

Protein Sequence (358 amino acids)

>RR42_RS05745 aminoglycoside phosphotransferase (Cupriavidus basilensis FW507-4G11)
MSTNVSNFEGTREVAEQQRFDMAALEAWMREHVAGFAGPLSIEQFKGGQSNPTFKLITPG
QTYVMRAKPGPKSKLLPSAHAIEREYRVMAALAGTDVPVARMYALCEDETVIGRAFYIME
FVAGRVLWDQSLPDMTPAERAAIYDEMNRVISALHTVDYKAIGLGDYGKPGNYFSRQIER
WTKQYKLSETESIPAMDSLMAWLPEHIPQEDADLTSIVHGDYRLDNLMFHPTEPRVLAVL
DWELSTLGHPMADFGYHCMSWHIAPGQFRGIAGLDHAGLGIPDEATYRRTYEQRTGRPIT
GDWNFYLAFSMFRIAGILQGIMKRVVDGTASSAQAADAGKRARPMAEMGWEYAKKAKQ