Protein Info for RR42_RS05335 in Cupriavidus basilensis FW507-4G11
Annotation: aldehyde oxidase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K13482, xanthine dehydrogenase large subunit [EC: 1.17.1.4] (inferred from 77% identity to bte:BTH_I1409)Predicted SEED Role
"Xanthine dehydrogenase, molybdenum binding subunit (EC 1.17.1.4)" in subsystem Purine Utilization (EC 1.17.1.4)
MetaCyc Pathways
- adenosine nucleotides degradation II (4/5 steps found)
- guanosine nucleotides degradation II (3/4 steps found)
- guanosine nucleotides degradation III (3/4 steps found)
- inosine 5'-phosphate degradation (3/4 steps found)
- purine nucleotides degradation II (aerobic) (8/11 steps found)
- ureide biosynthesis (5/7 steps found)
- adenosine nucleotides degradation I (5/8 steps found)
- guanosine nucleotides degradation I (2/4 steps found)
- purine nucleobases degradation II (anaerobic) (16/24 steps found)
- superpathway of guanosine nucleotides degradation (plants) (3/6 steps found)
- purine nucleotides degradation I (plants) (7/12 steps found)
- superpathway of purines degradation in plants (11/18 steps found)
- caffeine degradation III (bacteria, via demethylation) (1/7 steps found)
- theophylline degradation (1/9 steps found)
- caffeine degradation IV (bacteria, via demethylation and oxidation) (1/10 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 1.17.1.4
Use Curated BLAST to search for 1.17.1.4
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0C4Y664 at UniProt or InterPro
Protein Sequence (785 amino acids)
>RR42_RS05335 aldehyde oxidase (Cupriavidus basilensis FW507-4G11) MNKQTEPFLLDAASEARTAISTPQVGVSRPHESAHLHVAGTATYTDDIPELAGTLHAALG MSTRAHARIRSISLDKVRAAPGVVAVLSAEDIPAANECGPIIHDDPILANGLVQFIGQPI FVVVATSHDAARRAARLGTIEYEDLAPVLSPEAAHQAGSYVLPPMHLTRGEPASHIAAAV HRDKGNIRLGGQEQFYLEGQIAYAAPKENDGMHVWCSTQHPTEMQHAVAHMLGWHAHQVL VECRRMGGGFGGKESQSAMFACCAALAAWKLLCPVKLRPDRDDDMMITGKRHDFVFDYEV GHDADGRLDGVSVEMVSRAGFSADLSGPVMTRAICHFDNAYWLPNVQIDGYCGKTNTQSN TAFRGFGGPQGAFAMEYILDNVARTVGRDALDVRRANLYGKTERNVTPYGQTVEDNVIHE LLDELEATSAYRARREATRAFNATSPVLKKGIAITPVKFGISFNVAHFNQAGALVHVYND GSVLVNHGGTEMGQGLNTKVAMVVAHELGIRLERVRVTATDTSKVANTSATAASTGTDLN GKAAQDAARQIRERLAAFAARQAGVDADSVQFGDDLVVAGELRLDFSDLARQAYVARVQL WSDGFYTTPKLYWDQSKLQGRPFYYFAYGAACSEVLVDTLTGEWRLLRADVLHDAGRSLN PAIDIGQVEGGFIQGMGWLTTEELWWNKDGKLMTHAPSTYKIPTVNDCPEDFYVRLFEND NAEDSIHRSKAVGEPPLLLPFSVFFAIRDAVASVADYKVNPPLVAPATSEAILDAVDAVR VVRVV