Protein Info for RR42_RS05200 in Cupriavidus basilensis FW507-4G11

Annotation: aminopeptidase N

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 600 650 700 750 800 850 899 TIGR02414: aminopeptidase N" amino acids 14 to 897 (884 residues), 1220.8 bits, see alignment E=0 PF17900: Peptidase_M1_N" amino acids 89 to 186 (98 residues), 51.4 bits, see alignment E=3.1e-17 PF01433: Peptidase_M1" amino acids 226 to 440 (215 residues), 177.5 bits, see alignment E=6.1e-56 PF11940: DUF3458" amino acids 448 to 560 (113 residues), 79.8 bits, see alignment E=3.4e-26 PF17432: DUF3458_C" amino acids 565 to 898 (334 residues), 421.8 bits, see alignment E=4.3e-130

Best Hits

Swiss-Prot: 54% identical to PSA_ARATH: Puromycin-sensitive aminopeptidase (MPA1) from Arabidopsis thaliana

Predicted SEED Role

"Membrane alanine aminopeptidase N (EC 3.4.11.2)" (EC 3.4.11.2)

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 3.4.11.2

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4YCR4 at UniProt or InterPro

Protein Sequence (899 amino acids)

>RR42_RS05200 aminopeptidase N (Cupriavidus basilensis FW507-4G11)
MLRTDTPVTVHRKDYTPPAFAFEHVDLTLELDPARTVVTSILRFTRQAPGPLVLAGEALE
LLGVRLDGKPLEGAQQTPDSLTLPELPAQGTLEIATACQPAANTSLSGLYVSNGNFFTQC
EAEGFRKITYYLDRPDVMSTFRVTLRAQRAAYPVLLSNGNLISERELPDGRHEAIWEDPF
KKPAYLFALVAGKLECIEERIQSASGQEKLLQVWVEPQDLPKTRHAMDSLIHSIRWDEQR
FGLELDLDRFMIVAVGDFNMGAMENKGLNIFNTKYVLANAETATDADFGNIESVVGHEYF
HNWTGNRVTCRDWFQLSLKEGLTVFRDQEFSADMMGSESGRAVKRIEDVRMLRQVQFPED
AGPMAHPVRPDSYEEINNFYTVTVYEKGAEVVRMYQTLLGRDGFRKGMDLYFQRHDGQAV
TCDDFRAAMADANGRDLTQFGRWYSQAGTPVVAVRTAWDAATGTLALTLSQTSPKVGIET
RPGTPDKLPFHIPFALGLIDASGADLALQLEGESQPGATTRVLDFTEAEQTFRFINLPRG
AEPPLASLLRDFSAPVIIDAEYSEAQLTFLLAHDSDPFNRWEAGQRLTTRALLQLVAQGQ
AGGELRLDPALVAALRTVLNDQQLSPAFREQALTLPAEAYLAERMGVADPAAIHRARQFM
REALARALKADWLAAFEANATPLAYSPDAVSAGKRALRNLALGYLADSGDAAMQALAEAQ
YKAADNMTDRFAALSAMVNTFAPGREAALADFYQRFEQDPLVIDKWFSLQGTQRGTVGPQ
SAGHKGKHTIDTVRALMQHPAFNLRNPNRARSLIFSFCAANPAQFHAEDGSGYAFWAEQV
LALDAINPQVASRLARVMDRWQKYALPLRDRMRAALEQVAAASDLSRDVREIVSKALAP