Protein Info for RR42_RS04825 in Cupriavidus basilensis FW507-4G11

Annotation: glycine/betaine ABC transporter ATP-binding protein

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 391 TIGR01186: glycine betaine/L-proline transport ATP binding subunit" amino acids 19 to 366 (348 residues), 340.4 bits, see alignment E=6.7e-106 PF00005: ABC_tran" amino acids 23 to 168 (146 residues), 123.9 bits, see alignment E=1.1e-39 PF00571: CBS" amino acids 264 to 304 (41 residues), 34.6 bits, see alignment 2.9e-12 amino acids 313 to 366 (54 residues), 27.8 bits, see alignment 4e-10

Best Hits

Swiss-Prot: 66% identical to OSMV_SALTY: Osmoprotectant import ATP-binding protein OsmV (osmV) from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)

KEGG orthology group: K05847, osmoprotectant transport system ATP-binding protein (inferred from 85% identity to cti:RALTA_A0888)

Predicted SEED Role

"L-proline glycine betaine ABC transport system permease protein ProV (TC 3.A.1.12.1)" in subsystem Choline and Betaine Uptake and Betaine Biosynthesis (TC 3.A.1.12.1)

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y5X6 at UniProt or InterPro

Protein Sequence (391 amino acids)

>RR42_RS04825 glycine/betaine ABC transporter ATP-binding protein (Cupriavidus basilensis FW507-4G11)
MIELDQLTKTFRQKDGAEVRAVDAVSLTVPKGEICVFLGPSGCGKTTTLKMINRLIQPSS
GRVLIDGEDTSRVDEVTLRRKIGYVIQQIGLFPNMTIEENIMVVPRLLGWDKKRSRERAR
ELMSMVQLDPGKMLTRYPRELSGGQQQRIGVIRALAADAPVLLMDEPFGAVDPINRESIQ
NEFFLMQRQLGKTVIMVSHDIDEAIKLGDRVAVFRGGKLVQFDHPDALLARPADDFVQAF
IGHDNTLKRLLLVRAGDAATMAQTCSSGMPLAQAFAIMDEADVRHLPVVDDAQRALGYVT
RRDARAGRGVCADAMRPFMATAAFDEHLRIVLSRMYQHNTSWLPVVDADGVYLGEVTQES
IADYLSSGRSRGNAPVIQPPQAPAAIERNAA