Protein Info for RR42_RS03685 in Cupriavidus basilensis FW507-4G11
Annotation: GTP cyclohydrolase
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
No protein families (PFam or TIGRFam), signal peptides, or transmembrane helices were found in this protein.
Best Hits
KEGG orthology group: K01497, GTP cyclohydrolase II [EC: 3.5.4.25] (inferred from 53% identity to reu:Reut_B5741)Predicted SEED Role
No annotation
MetaCyc Pathways
- flavin biosynthesis I (bacteria and plants) (8/9 steps found)
- flavin biosynthesis III (fungi) (7/9 steps found)
- 6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia) (3/5 steps found)
- toxoflavin biosynthesis (3/7 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 3.5.4.25
Use Curated BLAST to search for 3.5.4.25
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0C4Y5F1 at UniProt or InterPro
Protein Sequence (89 amino acids)
>RR42_RS03685 GTP cyclohydrolase (Cupriavidus basilensis FW507-4G11) MPQNHAIYKGFKVSANVRRSLDESANDELARASFLATVTITQVSGDSGSLRLVPPLLEHV ARTPHDAIDLAVSYARTVIDDMSTFVKRK