Protein Info for RR42_RS02960 in Cupriavidus basilensis FW507-4G11

Annotation: triphosphoribosyl-dephospho-CoA synthase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 301 TIGR03132: triphosphoribosyl-dephospho-CoA synthase MdcB" amino acids 21 to 286 (266 residues), 326.6 bits, see alignment E=6.8e-102 PF01874: CitG" amino acids 23 to 284 (262 residues), 236.1 bits, see alignment E=3e-74

Best Hits

Swiss-Prot: 63% identical to MDCB_PSEU5: Probable 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase (mdcB) from Pseudomonas stutzeri (strain A1501)

KEGG orthology group: K13930, triphosphoribosyl-dephospho-CoA synthase [EC: 2.7.8.25] (inferred from 70% identity to reu:Reut_B4926)

Predicted SEED Role

"Triphosphoribosyl-dephospho-CoA synthetase (EC 2.7.8.25)" in subsystem Malonate decarboxylase (EC 2.7.8.25)

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.7.8.25

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y7A0 at UniProt or InterPro

Protein Sequence (301 amino acids)

>RR42_RS02960 triphosphoribosyl-dephospho-CoA synthase (Cupriavidus basilensis FW507-4G11)
MASLALPAGHRDDAFNPGAIALADLAVKALIDEAALSPKPGLVDGRGNGAHADLNLDLMR
ASARALHPAFAEMAAAGMCAAQPSVALRERLGALGREAEAAMMRATGGINTHRGAIWSLG
LLVGAAGLHRHGHSAHGIARTAGAIARLPDRHRPARTGNKGERACIDYGVAGARGQAQAG
FPHVLRAGLPELMRSRARGDAEPSARVNALLAIMQRLDDTCVLARAGREGLALMQQGASR
VLAAGGIGTLAGRRLLRQLEGGMLACNASPGGAADLLAATFFLDRLPPAARPANAPVQGD
K