Protein Info for RR42_RS02495 in Cupriavidus basilensis FW507-4G11
Annotation: cardiolipin synthase; exported protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
KEGG orthology group: K06132, putative cardiolipin synthase [EC: 2.7.8.-] (inferred from 74% identity to reh:H16_A0458)Predicted SEED Role
"Cardiolipin synthetase (EC 2.7.8.-)" in subsystem Glycerolipid and Glycerophospholipid Metabolism in Bacteria (EC 2.7.8.-)
MetaCyc Pathways
- cardiolipin biosynthesis II (3/3 steps found)
- cardiolipin and phosphatidylethanolamine biosynthesis (Xanthomonas) (3/4 steps found)
- superpathway of cardiolipin biosynthesis (bacteria) (9/13 steps found)
KEGG Metabolic Maps
- Aminophosphonate metabolism
- Glycerophospholipid metabolism
- High-mannose type N-glycan biosynthesis
- Nucleotide sugars metabolism
- Sphingolipid metabolism
Isozymes
Compare fitness of predicted isozymes for: 2.7.8.-
Use Curated BLAST to search for 2.7.8.-
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Compare to protein structures
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A0C4YBG0 at UniProt or InterPro
Protein Sequence (439 amino acids)
>RR42_RS02495 cardiolipin synthase; exported protein (Cupriavidus basilensis FW507-4G11) MSSIPPPPRPPRAPPPGLTASRDDARASAPRHAGPLRSEWRRGRPLGGNAVRLLRGGNAF FPALVAAIDQAAFSVSLETYIYADDAVGAAVSDALIRAAGRGVAVHLVVDGFGAGDMPAG LAEHLREGGVCLKIFRPLRRFSLARRNLRRLHRKLAVIDQQIGFVGGINIIDDNNHGPFE STGLGPRYDFAVEVRGPLVNQIALTAERLWWQLSLRGEMRSVGLAGVAAEFPLITDLPLP RQDQAGGMRAVLLLRDNLRNRRAIEREYLQALGGARREVIIANAYFLPGHKMRRALLACR KRGVRVRLLLQGRVEYRLQHYATHSLYATLLGAGVEIYEYADSFLHAKVAVVDDAWATVG SSNMDPFSLLLAREANVAVYDGAFCAELRQELEHAIASRSIEVKAATHARRSAVRRMANW AAYMVLRVGVIIAGVTGRY