Protein Info for RR42_RS02240 in Cupriavidus basilensis FW507-4G11

Annotation: D-galactarate dehydratase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF04295: GD_AH_second
  • amino acids 12 to 136 (125 residues), 114.8 bits, E=3.2e-37
• PF20629: GD_AH_C
  • amino acids 146 to 387 (242 residues), 289.3 bits, E=2.2e-90

Best Hits

Swiss-Prot: 80% identical to SUYB_CHRSD: (2R)-sulfolactate sulfo-lyase subunit beta (suyB) from Chromohalobacter salexigens (strain DSM 3043 / ATCC BAA-138 / NCIMB 13768)

KEGG orthology group: K01685, altronate hydrolase [EC: 4.2.1.7] (inferred from 94% identity to cti:RALTA_B0840)

MetaCyc: 80% identical to R-sulfolactate sulfo-lyase B subunit (Chromohalobacter salexigens DSM 3043)
Sulfolactate sulfo-lyase. [EC: 4.4.1.24]

Predicted SEED Role

"Altronate dehydratase (EC 4.2.1.7)" (EC 4.2.1.7)

MetaCyc Pathways

• (R)-cysteate degradation (2/3 steps found)
• sulfolactate degradation I (2/3 steps found)
• D-galacturonate degradation I (3/5 steps found)
• superpathway of hexuronide and hexuronate degradation (5/10 steps found)
• superpathway of microbial D-galacturonate and D-glucuronate degradation (15/31 steps found)

KEGG Metabolic Maps

• Cysteine metabolism
• Pentose and glucuronate interconversions

Isozymes

Compare fitness of predicted isozymes for: 4.2.1.7

Use Curated BLAST to search for 4.2.1.7 or 4.4.1.24

Sequence Analysis Tools

See A0A0C4XZB7 at UniProt or InterPro

Protein Sequence (391 amino acids)

>RR42_RS02240 D-galactarate dehydratase (Cupriavidus basilensis FW507-4G11)
MSVIDNQTTFRGYRRDNGRVGVRNHVIILPLDDLSNAAAEAVAVAIKGTMAIPHPYGRLQ
FGPDLDLHFRTLIGAGSNPNVAAVVVIGIEDGWTKKVVDGIAKTGKPVVGFGIEGHGDHD
TIMRASKAAKEFVQYATGLHRVECPISDLWISTKCGESDTTSGCGANPTVGNAFDKLHPL
GTTLVFGETSELTGGEHIVAARCANDKVRDDFMKMFNRYQGMIDRWKTTDLSESQPTKGN
IAGGLTTIEEKALGNIQKIGKKCTVDGVLDKAEEPTGPGLWFMDSSSAAAEMVTLCAASG
YVVHFFPTGQGNVIGNPIVPVIKLCANPRTVRLMSEHMDVDCSGLLQREQTLDQTGDKLL
ECMMATINGRWTAAEALGHREFVLTRIHESA