Protein Info for RR42_RS01460 in Cupriavidus basilensis FW507-4G11

Annotation: glucosamine--fructose-6-phosphate aminotransferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01135: glutamine-fructose-6-phosphate transaminase (isomerizing)
  • amino acids 2 to 612 (611 residues), 812.7 bits, E=1e-248
• PF13522: GATase_6
  • amino acids 66 to 197 (132 residues), 71.7 bits, E=1.2e-23
• PF13537: GATase_7
  • amino acids 83 to 197 (115 residues), 52 bits, E=1.3e-17
• PF01380: SIS
  • amino acids 294 to 420 (127 residues), 88.8 bits, E=5.7e-29
  • amino acids 466 to 592 (127 residues), 80.7 bits, E=1.7e-26

Best Hits

Swiss-Prot: 86% identical to GLMS_RALSO: Glutamine--fructose-6-phosphate aminotransferase [isomerizing] (glmS) from Ralstonia solanacearum (strain GMI1000)

KEGG orthology group: K00820, glucosamine--fructose-6-phosphate aminotransferase (isomerizing) [EC: 2.6.1.16] (inferred from 90% identity to reu:Reut_A0230)

Predicted SEED Role

"Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] (EC 2.6.1.16)" in subsystem Sialic Acid Metabolism or UDP-N-acetylmuramate from Fructose-6-phosphate Biosynthesis (EC 2.6.1.16)

MetaCyc Pathways

• O-antigen building blocks biosynthesis (E. coli) (10/11 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis I (5/5 steps found)
• UDP-N-acetyl-D-glucosamine biosynthesis II (4/6 steps found)
• chitin biosynthesis (6/9 steps found)
• UDP-N-acetyl-D-galactosamine biosynthesis III (2/6 steps found)
• CMP-legionaminate biosynthesis I (2/10 steps found)
• superpathway of UDP-N-acetylglucosamine-derived O-antigen building blocks biosynthesis (6/24 steps found)
• superpathway of mycolyl-arabinogalactan-peptidoglycan complex biosynthesis (12/33 steps found)

KEGG Metabolic Maps

• Aminosugars metabolism
• Glutamate metabolism
• Nucleotide sugars metabolism

Isozymes

Compare fitness of predicted isozymes for: 2.6.1.16

Use Curated BLAST to search for 2.6.1.16

Sequence Analysis Tools

See A0A0C4Y497 at UniProt or InterPro

Protein Sequence (612 amino acids)

>RR42_RS01460 glucosamine--fructose-6-phosphate aminotransferase (Cupriavidus basilensis FW507-4G11)
MCGIVGGVSSRNIVPVLIEGLRRLEYRGYDSCGVAVVRDNALERARTVSRVADLDEQTRA
SGLAGMTGVAHTRWATHGKPDTTNAHPHFSGESIALVHNGIIENYEPLREELRAAGYGFE
SQTDTEVVAHLIHQVYTYPSSATRGDLFASVRAVTKRLHGAYAIAVFSKDHPERVVGARA
GSPLVVALGDNESFLASDALAVAGTANRIVYLEEGDVVEITREGATIRDAHDHLVEREVR
VVETHAAAVELGPYHHFMQKEIFEQPRALGDTLEGIDAITPELFGETAQSVFSEIDSVLI
LACGTSYYSGCTAKYWLESVAKIPTQVEVASEYRYRETVPNPRALVVVISQSGETADTMA
ALRHAKSLGHSHTLAVCNVSTSAMVRETALRFLTRAGTEIGVASTKAFTTQLAALYMLTL
ALAKVRGRLTAEAEAAALTNLRHLPVALHGVLALEPQIISWSEDFARRENALFLGRGLHY
PIALEGALKLKEISYIHAEAYPAGELKHGPLALVTEAMPVVTVAPNDALLEKLKSNIQEV
RARGGRLYVFADSDTHIHSTEGIQVIRLPEHYGDLSPILHVVPLQLLAYHTACARGTDVD
KPRNLAKSVTVE