Protein Info for RR42_RS00620 in Cupriavidus basilensis FW507-4G11

Annotation: XRE family transcriptional regulator

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 319 transmembrane" amino acids 240 to 258 (19 residues), see Phobius details amino acids 271 to 291 (21 residues), see Phobius details PF00126: HTH_1" amino acids 25 to 84 (60 residues), 78 bits, see alignment E=4.1e-26 PF03466: LysR_substrate" amino acids 109 to 306 (198 residues), 118.6 bits, see alignment E=2.7e-38

Best Hits

KEGG orthology group: K03566, LysR family transcriptional regulator, glycine cleavage system transcriptional activator (inferred from 87% identity to reh:H16_A0120)

Predicted SEED Role

"Glycine cleavage system transcriptional activator GcvA" in subsystem Glycine cleavage system or Orphan regulatory proteins

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Compare to protein structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A0C4Y3U8 at UniProt or InterPro

Protein Sequence (319 amino acids)

>RR42_RS00620 XRE family transcriptional regulator (Cupriavidus basilensis FW507-4G11)
MALKGAWERDLPRGWHRELPRLPGLTALRAFEAAARHESFSRAATELFVTHGAVSHQIRA
LEEELGQALFERNGKRVTLTPGGRAYAGRVREALLEIADATRALQAGNRDKRLTISTMPS
FAARWLTPRIGSFIEQHPELDVELLSSNTLVDFGREEVDIALRMGSGDYPGLYVEKLLDD
VFFPVCSPAFNGGKLPARPQDMKGMSLLRGEGDPWKPWFEAAGLDWPEPRKGLLLEDSSL
LLQAAAAGQGIALIRSSLAYNDLLSGRVVRLFDVSITCPWLLYFVCSAGMLEAPKVKAFR
AWLLPEMEAFRGILAQWEG