Protein Info for RALBFv3_RS22540 in Ralstonia solanacearum IBSBF1503

Annotation: Bcr/CflA family drug resistance efflux transporter

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 415 transmembrane" amino acids 20 to 40 (21 residues), see Phobius details amino acids 54 to 74 (21 residues), see Phobius details amino acids 86 to 107 (22 residues), see Phobius details amino acids 112 to 132 (21 residues), see Phobius details amino acids 144 to 168 (25 residues), see Phobius details amino acids 174 to 194 (21 residues), see Phobius details amino acids 223 to 244 (22 residues), see Phobius details amino acids 258 to 277 (20 residues), see Phobius details amino acids 289 to 309 (21 residues), see Phobius details amino acids 316 to 341 (26 residues), see Phobius details amino acids 351 to 373 (23 residues), see Phobius details amino acids 379 to 400 (22 residues), see Phobius details TIGR00710: drug resistance transporter, Bcr/CflA subfamily" amino acids 18 to 395 (378 residues), 301.8 bits, see alignment E=4.8e-94 PF07690: MFS_1" amino acids 26 to 366 (341 residues), 161.1 bits, see alignment E=3.5e-51 PF00083: Sugar_tr" amino acids 55 to 196 (142 residues), 37.8 bits, see alignment E=1.2e-13

Best Hits

KEGG orthology group: K07552, MFS transporter, DHA1 family, bicyclomycin/chloramphenicol resistance protein (inferred from 90% identity to rsl:RPSI07_mp0138)

Predicted SEED Role

"Multidrug resistance transporter, Bcr/CflA family" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

Find the best match in UniProt

Protein Sequence (415 amino acids)

>RALBFv3_RS22540 Bcr/CflA family drug resistance efflux transporter (Ralstonia solanacearum IBSBF1503)
MSLNESAAPPAAAQAHGLRILAILSTLMAFASISTDLYLPALPAMGTALHAGTGTIELTI
SGYLIGFSLGQLVWGPVGDRYGRRLPIAIGLVLFIVGSAGCAVSTSAGMMIGWRALQAVG
ACASVVLARAMVRDLFAGHRAAQMLSTLMTVMAVAPLLGPSVGGLILHVASWRAIFWTLA
GVGVATLAALCGLPETLPAPQRSREPLRRALVRYGELLRHRRLLGYAGAGGFFYGGMYAY
IAGTPFAYITYHHLSPQVYGLLFGTGIVGIMVTNQVNARLVARFGGDRLMRAGTVGAALA
GALLALTAWTDWGGLAGLVLPLFLFLSATGFIVANSIAGALGSFAERAGSVSALVGSLQY
GSGIIGSALVGAFADGTPWPMGCVIALAGLGSVLCARLVAPPEPAGLRIVGPGAP