Protein Info for RALBFv3_RS17345 in Ralstonia solanacearum IBSBF1503

Annotation: CoA transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF02515: CoA_transf_3
  • amino acids 10 to 371 (362 residues), 381.6 bits, E=2.1e-118

Best Hits

KEGG orthology group: None (inferred from 94% identity to rsl:RPSI07_mp1411)

Predicted SEED Role

"Hydroxymethylglutaryl-CoA lyase (EC 4.1.3.4)" in subsystem HMG CoA Synthesis or Leucine Degradation and HMG-CoA Metabolism (EC 4.1.3.4)

MetaCyc Pathways

• L-leucine degradation I (5/6 steps found)
• ketogenesis (4/5 steps found)
• mevalonate degradation (1/2 steps found)

KEGG Metabolic Maps

• Butanoate metabolism
• Synthesis and degradation of ketone bodies
• Valine, leucine and isoleucine degradation

Isozymes

Compare fitness of predicted isozymes for: 4.1.3.4

Use Curated BLAST to search for 4.1.3.4

Protein Sequence (383 amino acids)

>RALBFv3_RS17345 CoA transferase (Ralstonia solanacearum IBSBF1503)
MQHDNESLPLAGIRVLEFTHLVMGPTCGMILADLGAEVIKIEPPGGDKTRGLPGPGIGLF
RAFNRNKKSVVLDITTDEGRATARELAGRCDVVLENFRPGLMEQLGLDYATLSAAYPHLI
YVSHKGFLPGPYEHRLALDEVVQMMGGLSYMTGPAGRPLRAGTSVNDIMGGMFGAIGVLA
ALRERDRTGRGQEIQSALFENCVFLASQHMQQYAMTGEPPPPMPARALAWSVYDVFTLAD
GEQLFIGAVSDKQFATLCTVLGHPALLDNPQYATNALRVAVRPQLLEELGGILAGHDAKT
LAPRLEAAGIPYAPIVRPDQLLDDPHLKASGGLVPMQMDDGSVGPTVLLPLLMGGRRPGV
RSPLPQPGEHTEAVLAALQERTA