Protein Info for RALBFv3_RS11505 in Ralstonia solanacearum IBSBF1503

Annotation: acyl CoA:acetate/3-ketoacid CoA transferase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• PF01144: CoA_trans
  • amino acids 5 to 251 (247 residues), 62.4 bits, E=4.1e-21
• PF16957: Mal_decarbox_Al
  • amino acids 182 to 259 (78 residues), 26.8 bits, E=1.7e-10

Best Hits

KEGG orthology group: None (inferred from 98% identity to rsc:RCFBP_21013)

Predicted SEED Role

"Acetyl-CoA:acetoacetyl-CoA transferase, alpha subunit (EC 2.8.3.8)" in subsystem Acetyl-CoA fermentation to Butyrate (EC 2.8.3.8)

MetaCyc Pathways

• acetoacetate degradation (to acetyl CoA) (2/2 steps found)
• acetyl-CoA fermentation to butanoate (5/7 steps found)
• pyruvate fermentation to acetone (3/5 steps found)
• 4-aminobutanoate degradation V (3/7 steps found)
• L-glutamate degradation V (via hydroxyglutarate) (5/10 steps found)
• gallate degradation III (anaerobic) (5/11 steps found)
• L-glutamate degradation XI (reductive Stickland reaction) (2/7 steps found)
• superpathway of Clostridium acetobutylicum solventogenic fermentation (6/13 steps found)
• succinate fermentation to butanoate (1/7 steps found)
• superpathway of Clostridium acetobutylicum acidogenic and solventogenic fermentation (8/17 steps found)

KEGG Metabolic Maps

• Benzoate degradation via CoA ligation
• Butanoate metabolism
• Propanoate metabolism

Isozymes

No predicted isozymes

Use Curated BLAST to search for 2.8.3.8

Protein Sequence (554 amino acids)

>RALBFv3_RS11505 acyl CoA:acetate/3-ketoacid CoA transferase (Ralstonia solanacearum IBSBF1503)
MQVITAEEAARLVQPGWTVACAGFVGAGHAEAVTHALERRFLATGEPRDLTLVYSAGQGD
RAKRGVNHFGNPGMTRCVVGGHWRSATRLAALALAEQCDAFNLPQGVLTHLYRAIAGGKP
GVLTRIGLHTFVDPRTSLDARYQGAAINARARAARAAGTASWVEYERFRGEDYLFYPRFP
LHCVLLRGTAADPRGNISTHEEAFHHELLAMAQAARNAGGIVIVQVRRLVDRHDNLQAIH
VPGILVDYVVVAEDPAEHQMTFGEAFNPVYLRPWQGEAIQLREDALEAGAALEASLHGAL
DARTLVQRRAVLELMAQRPRVVNLGVGMPAAVGALAEQEGARGFTLTVEAGPIGGTPADG
LSFGASAYPEAVVDQPAQFDFYEGGGIDLAILGLAELDGQGNVNVSLFGEGGDTIVAGVG
GFINITQSARALVFMGTLTAGGLQVEAGEGRLRIVREGRLKKIVPAVSHLTFNGEYAARS
GIPVRYVTERAVFEMRDDGHGGRRLTLTEIAPGVDLLRDVLDQCAAEVAVAADLREMDSR
IFRRGPMCAGPAAA