Protein Info for Psyr_4462 in Pseudomonas syringae pv. syringae B728a

Annotation: diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 366 PF00383: dCMP_cyt_deam_1" amino acids 1 to 94 (94 residues), 70.5 bits, see alignment E=1.5e-23 TIGR00326: riboflavin biosynthesis protein RibD" amino acids 1 to 356 (356 residues), 391.7 bits, see alignment E=3.2e-121 PF14437: MafB19-deam" amino acids 4 to 136 (133 residues), 48.1 bits, see alignment E=1.6e-16 TIGR00227: riboflavin-specific deaminase C-terminal domain" amino acids 140 to 357 (218 residues), 176.7 bits, see alignment E=4.8e-56 PF01872: RibD_C" amino acids 141 to 354 (214 residues), 164.3 bits, see alignment E=4.7e-52

Best Hits

KEGG orthology group: K11752, diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC: 1.1.1.193 3.5.4.26] (inferred from 100% identity to psb:Psyr_4462)

Predicted SEED Role

"Diaminohydroxyphosphoribosylaminopyrimidine deaminase (EC 3.5.4.26) / 5-amino-6-(5-phosphoribosylamino)uracil reductase (EC 1.1.1.193)" in subsystem Riboflavin, FMN and FAD metabolism (EC 1.1.1.193, EC 3.5.4.26)

MetaCyc Pathways

KEGG Metabolic Maps

Isozymes

No predicted isozymes

Use Curated BLAST to search for 1.1.1.193 or 3.5.4.26

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q4ZMY0 at UniProt or InterPro

Protein Sequence (366 amino acids)

>Psyr_4462 diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase (Pseudomonas syringae pv. syringae B728a)
MARALELARKGLYSTHPNPRVGCVIVREGRIVGEGWHARAGEPHAEVHALRQAGELARGA
TAYVTLEPCSHQGRTPPCADALIEAGLTRVVAAMQDPNPEVSGRGLLRLMNAGIGVQCGV
LESEARALNKGFLKRMETGLPYVRVKMAMSLDGRTAMASGESQWITGPEARSAVQRLRAQ
SSVVLSGADTVLADKARLTVRPDELGLDAELTALAAARAPLRVLIDGRLRVPLDAPFFQA
GSALVVTCAAASARGRYQEEGHEMLALADSAGHVDLRRLMDELAARGVNEVLVEAGPRLA
GAFARLGLVDEFQLFIAGKFLGSSARPLLDLPLAQMSEALELNIVEMRAVGNDWRVIALP
VRTPGV