Protein Info for Psyr_4381 in Pseudomonas syringae pv. syringae B728a

Annotation: arginine decarboxylase

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01273: arginine decarboxylase
  • amino acids 14 to 636 (623 residues), 888 bits, E=1.7e-271
• PF02784: Orn_Arg_deC_N
  • amino acids 100 to 350 (251 residues), 136.3 bits, E=1.8e-43
• PF17810: Arg_decarb_HB
  • amino acids 377 to 458 (82 residues), 66.4 bits, E=3.5e-22
• PF17944: Arg_decarbox_C
  • amino acids 586 to 635 (50 residues), 54.3 bits, 2.2e-18

Best Hits

Swiss-Prot: 99% identical to SPEA_PSESM: Biosynthetic arginine decarboxylase (speA) from Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000)

KEGG orthology group: K01585, arginine decarboxylase [EC: 4.1.1.19] (inferred from 100% identity to psb:Psyr_4381)

MetaCyc: 87% identical to arginine decarboxylase, biosynthetic (Pseudomonas aeruginosa)
Arginine decarboxylase. [EC: 4.1.1.19]

Predicted SEED Role

"Biosynthetic arginine decarboxylase (EC 4.1.1.19)" in subsystem Acid resistance mechanisms or Arginine and Ornithine Degradation or Polyamine Metabolism (EC 4.1.1.19)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (16/17 steps found)
• superpathway of polyamine biosynthesis I (7/8 steps found)
• superpathway of polyamine biosynthesis II (7/8 steps found)
• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (3/3 steps found)
• putrescine biosynthesis II (3/3 steps found)
• arginine dependent acid resistance (1/1 steps found)
• superpathway of putrescine biosynthesis (3/4 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (1/2 steps found)
• putrescine biosynthesis I (1/2 steps found)
• spermidine biosynthesis III (2/4 steps found)
• superpathway of L-arginine and L-ornithine degradation (7/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (5/11 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.19

Use Curated BLAST to search for 4.1.1.19

Sequence Analysis Tools

See Q4ZN61 at UniProt or InterPro

Protein Sequence (637 amino acids)

>Psyr_4381 arginine decarboxylase (Pseudomonas syringae pv. syringae B728a)
MSVRRTRKDDGSQWTVADSRSVYGIRHWGAGYFAINEAGRVEVRPNGPDSSPIDLYEQVD
NLRKSGLSLPLLVRFPDILQDRVRQLTGAFDSNIARLEYQSKYTALYPIKVNQQEAVVEN
IIATQNVSIGLEAGSKPELMAVLALAPKGGTIVCNGYKDREFIRLALMGQKLGHNVFIVI
EKESEVELVIEEAAELKVAPQVGLRVRLSSLASSKWADTGGEKSKFGLSAAQLLSVVERF
RKAGLDQGIRLLHFHMGSQIANLADYQHGFKEAIRYYGELRKLGLPVDYIDVGGGLGVDY
DGTHSRNASSINYDMDDYAGVVVGMLKEFCDAQSLPHPHIFSESGRSLTAHHAMLVVQVT
DVEKHNDEVPEIADKASLPETVQWLVDLLGPTDIEMVTETYWRATHYMSDIAAQYADGKI
SLSEKALGEQCYFAVCRRLYNSLKARQRSHRQVLDELNDKLADKYICNFSVFQSLPDTWA
IGQVLPILPLHRLNEEPVRRAVLQDLTCDSDGKIKQYVDEQSIETSMPVHSLNEGEDYLL
GIFLVGAYQEILGDMHNLFGDTDSVNIYQNPDGSVYHAGIETHDTIEDMLRYVHLSPEEL
MTHYRDKVASAKITPRERTYFLDALRLGLTRSSYLSS