Protein Info for Psyr_1493 in Pseudomonas syringae pv. syringae B728a

Annotation: Twin-arginine translocation pathway signal:Copper-resistance protein CopA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 450 500 550 606 signal peptide" amino acids 1 to 33 (33 residues), see Phobius details TIGR01480: copper-resistance protein, CopA family" amino acids 4 to 605 (602 residues), 996.7 bits, see alignment E=3.6e-304 TIGR01409: Tat (twin-arginine translocation) pathway signal sequence" amino acids 5 to 32 (28 residues), 27.6 bits, see alignment (E = 2.6e-10) PF07732: Cu-oxidase_3" amino acids 55 to 163 (109 residues), 130.6 bits, see alignment E=5e-42 amino acids 518 to 604 (87 residues), 29.1 bits, see alignment E=1.3e-10 PF00394: Cu-oxidase" amino acids 172 to 346 (175 residues), 89.8 bits, see alignment E=3.1e-29 PF07731: Cu-oxidase_2" amino acids 488 to 605 (118 residues), 106.1 bits, see alignment E=2e-34

Best Hits

Swiss-Prot: 96% identical to COPA_PSEUB: Copper resistance protein A (copA) from Pseudomonas syringae pv. tomato

KEGG orthology group: None (inferred from 100% identity to psb:Psyr_1493)

Predicted SEED Role

"Multicopper oxidase" in subsystem Copper homeostasis

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See Q4ZWC9 at UniProt or InterPro

Protein Sequence (606 amino acids)

>Psyr_1493 Twin-arginine translocation pathway signal:Copper-resistance protein CopA (Pseudomonas syringae pv. syringae B728a)
MESRTSRRTFVKGLAAAGVLGGLGLWRSPSWAASGSAALSVLSGTEYDLSIGEMLVNITG
KRRTAMAINGGLPGPLLRWKEGDTVTLRVRNRLDAATSIHWHGIILPPNMDGVPGLSFAG
IEPGGVYVYQFKLQQNGTYWYHSHSGFQEQVGVYGPLVIEAKEPEPFKYDSEHVVMLTDW
TDEDPVALMRTLKKQSDYYNFHKRTVGDFVNDVADKGWAATVADRKMWAEMKMNPTDLAD
VSGATYTYLLNGQAPNMNWTGLFRPGEKVRLRFINGSAMTYFDIRIPGLKMTVVASDGQY
VNPVKVDELRIAVAETFDVIVEPTAEAYTVFAQSMDRTGYARGTLAVREGLVAQVPPLDA
RPLVTMDDMGMGGMDHGSMGSMDSGADDGMQTMSSMGGNSMPAMDHSKMSTMQGMDHGAM
PGMDHDSMGGMVMQSHPASEKNNPLVDMQAMSPTAKLNDPGLGLRNNGRKVLTYADLKST
FEDPDGREPSRTIELHLTGHMEKFAWSFDGIKFADAQPLVLKYGERVRIVLVNDTMMTHP
IHLHGMWSDLEDEDGNFRVRKHTIDMPPGSKRSYRVTADALGRWAYHCHLLYHMEMGMFR
EVRVEE