Protein Info for Pf6N2E2_4738 in Pseudomonas fluorescens FW300-N2E2

Annotation: Two-component response regulator CreC

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 150 200 250 300 350 400 472 transmembrane" amino acids 6 to 26 (21 residues), see Phobius details amino acids 184 to 206 (23 residues), see Phobius details PF00672: HAMP" amino acids 201 to 251 (51 residues), 33.4 bits, see alignment 7.1e-12 PF00512: HisKA" amino acids 259 to 319 (61 residues), 57.4 bits, see alignment E=1.9e-19 PF02518: HATPase_c" amino acids 369 to 472 (104 residues), 58.3 bits, see alignment E=1.5e-19

Best Hits

KEGG orthology group: K07641, two-component system, OmpR family, sensor histidine kinase CreC [EC: 2.7.13.3] (inferred from 94% identity to pba:PSEBR_a5201)

Predicted SEED Role

"Two-component response regulator CreC"

Isozymes

Compare fitness of predicted isozymes for: 2.7.13.3

Use Curated BLAST to search for 2.7.13.3

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A160A279 at UniProt or InterPro

Protein Sequence (472 amino acids)

>Pf6N2E2_4738 Two-component response regulator CreC (Pseudomonas fluorescens FW300-N2E2)
MSLGIRIFLVYVLFIGLTGYFVLNTVMEEIRPGVRQSTEETLVDTANLMAEILRDDFKAG
TLNQNRWPQLLKAYGERQPAATIWGLPKNQVSHRIYVTDAKGIVVLDSSGVAVGQDYSRW
NDVYLTLRGHYGARSTRSVADDPTSSVMHVGAPIRDNGRIIGVVTVAKPNSSLQPYVDRT
ERRLLAYGAGLIVLGLLLGALLSWWLSAALRRLTTYAQAVSQGRRVEVPHYRGGEFEQLA
GAVEHMRTQLEGKAYVERYVHTLTHELKSPLAAIRGAAELLQSDMPAAQHQRFVSNIESE
SVRMQQLIERLLNLAQIEQRQGLEDVVAVPLVALLDELLEARGGWIESRQLKVEQRIAAD
LTLTGEAFLLRQALGNLLENALDFTPAHGLLRISAERIDNHVEIRLFNQAEPIPDYALPR
LSERFYSLPRPDSGRKSTGLGLNFVEEVVQLHGGEFRIGNVEGGVEVVLRLP