Protein Info for Pf6N2E2_3718 in Pseudomonas fluorescens FW300-N2E2
Annotation: Putative histidine ammonia-lyase protein
These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.
Protein Families and Features
Best Hits
Swiss-Prot: 38% identical to HUTH_DEIRA: Histidine ammonia-lyase (hutH) from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
KEGG orthology group: K01745, histidine ammonia-lyase [EC: 4.3.1.3] (inferred from 99% identity to pba:PSEBR_a451)Predicted SEED Role
"Putative histidine ammonia-lyase protein"
MetaCyc Pathways
- L-histidine degradation II (5/5 steps found)
- L-histidine degradation VI (7/8 steps found)
- L-histidine degradation I (4/4 steps found)
- L-histidine degradation III (4/6 steps found)
KEGG Metabolic Maps
Isozymes
Compare fitness of predicted isozymes for: 4.3.1.3
Use Curated BLAST to search for 4.3.1.3
Sequence Analysis Tools
PaperBLAST (search for papers about homologs of this protein)
Search CDD (the Conserved Domains Database, which includes COG and superfam)
Predict protein localization: PSORTb (Gram-negative bacteria)
Predict transmembrane helices and signal peptides: Phobius
Check the current SEED with FIGfam search
Find homologs in fast.genomics or the ENIGMA genome browser
See A0A159ZYB1 at UniProt or InterPro
Protein Sequence (512 amino acids)
>Pf6N2E2_3718 Putative histidine ammonia-lyase protein (Pseudomonas fluorescens FW300-N2E2) MPTLEPVTFGERPLRIEDVLALANRQAPTQLQDDPAFRQRIAKGAQFLDSLLDKEGVIYG VTTGYGDSCVVAVPLHHVEALPRHLYTFHGCGLGKLLDAQATRAVLAARLQSLCHGVSGV RVELLERLQAFLEHDILPLIPEEGSVGASGDLTPLSYVAATLSGEREVMFRGERRLAADV HRELGWTPLVLRPKEALALMNGTAVMTGLACLAFARADYLLQLATRITALNVVALQGNPE HFDERLFAAKPHPGQMQVAAWLRKDLAIDAPTAPLHRLQDRYSLRCAPHVLGVLADSLGW LRAFIETELNSANDNPIIDAEAERVLHGGHFYGGHIAFAMDSLKNLVANVADLLDRQLAL LVDERYNHGLPSNLSGASADRAMLNHGFKAVQIGTSAWTAEALKNTMPASVFSRSTECHN QDKVSMGTIAARDAIRVLELTEQVAAATLLAANQGVWLRSRAEDARPLPPALAAMHEQLA EDFAPVIEDRALEGELRLCLQRIAEQHWRLHA