Protein Info for Pf6N2E2_3504 in Pseudomonas fluorescens FW300-N2E2

Annotation: Biosynthetic arginine decarboxylase (EC 4.1.1.19)

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

• TIGR01273: arginine decarboxylase
  • amino acids 14 to 636 (623 residues), 891.1 bits, E=2.1e-272
• PF02784: Orn_Arg_deC_N
  • amino acids 100 to 350 (251 residues), 130.7 bits, E=9.5e-42
• PF17810: Arg_decarb_HB
  • amino acids 377 to 458 (82 residues), 70.7 bits, E=1.5e-23
• PF17944: Arg_decarbox_C
  • amino acids 586 to 635 (50 residues), 57.7 bits, 2e-19

Best Hits

Swiss-Prot: 94% identical to SPEA_PSEPK: Biosynthetic arginine decarboxylase (speA) from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)

KEGG orthology group: K01585, arginine decarboxylase [EC: 4.1.1.19] (inferred from 100% identity to pba:PSEBR_a641)

MetaCyc: 87% identical to arginine decarboxylase, biosynthetic (Pseudomonas aeruginosa)
Arginine decarboxylase. [EC: 4.1.1.19]

Predicted SEED Role

"Biosynthetic arginine decarboxylase (EC 4.1.1.19)" in subsystem Acid resistance mechanisms or Arginine and Ornithine Degradation or Polyamine Metabolism (EC 4.1.1.19)

MetaCyc Pathways

• superpathway of arginine and polyamine biosynthesis (14/17 steps found)
• superpathway of L-arginine and L-ornithine degradation (11/13 steps found)
• superpathway of L-arginine, putrescine, and 4-aminobutanoate degradation (9/11 steps found)
• L-arginine degradation IV (arginine decarboxylase/agmatine deiminase pathway) (3/3 steps found)
• putrescine biosynthesis II (3/3 steps found)
• L-arginine degradation III (arginine decarboxylase/agmatinase pathway) (2/2 steps found)
• putrescine biosynthesis I (2/2 steps found)
• arginine dependent acid resistance (1/1 steps found)
• superpathway of putrescine biosynthesis (3/4 steps found)
• superpathway of polyamine biosynthesis I (5/8 steps found)
• superpathway of polyamine biosynthesis II (5/8 steps found)
• spermidine biosynthesis III (1/4 steps found)

KEGG Metabolic Maps

• Arginine and proline metabolism
• Urea cycle and metabolism of amino groups

Isozymes

Compare fitness of predicted isozymes for: 4.1.1.19

Use Curated BLAST to search for 4.1.1.19

Sequence Analysis Tools

See A0A165ZGG3 at UniProt or InterPro

Protein Sequence (637 amino acids)

>Pf6N2E2_3504 Biosynthetic arginine decarboxylase (EC 4.1.1.19) (Pseudomonas fluorescens FW300-N2E2)
MSVRRTRKDDGSQWTVADSRSVYGIRHWGAGYFAINEAGRVEVRPNGPDSSPIDLFEQVD
QLRQSGLSLPLLVRFPDILQDRVRQLTGAFDSNIARLEYQSKYTALYPIKVNQQEAVIEN
IIATQNVSIGLEAGSKPELLAVLALAPKGGTIVCNGYKDREFIRLALMGQKLGHNVFIVI
EKESEVGLVIEEAATLKVKPQVGLRVRLSSLASSKWADTGGEKSKFGLSAAQLLSVVERF
RAAGLDQGIRLLHFHMGSQIANLADYQHGFKEAIRYYGELRNLGLPVDHIDVGGGLGVDY
DGTHSRNASSINYDMDDYAGVVVGMLKEFCDAQSLPHPNIFSESGRSLTAHHAMLVVQVT
DVEKHNDDVPVIDNKQELPETVQWLVDLLGPTDIEMVTETYWRATHYMSDVATQYADGKL
TLAEKALAEQCYFAVCRRLHNSLKARQRSHRQVLDELNDKLADKYICNFSVFQSLPDTWA
IGQVLPILPLHRLDEEPLRRAVLQDLTCDSDGKIKQYVDEQSIETSLPVHALKPDEDYLL
GIFLVGAYQEILGDMHNLFGDTDSVNIYQNADGSVYHAGIETHDTIEDMLRYVHLSPEEL
MTHYRDKCASARISAAERTQFLDALRLGLTRSSYLSS