Protein Info for Pf6N2E2_2799 in Pseudomonas fluorescens FW300-N2E2

Annotation: Fosfomycin resistance protein FosA

These analyses and tools can help you predict a protein's function, but be skeptical. For enzymes, over 10% of annotations from KEGG or SEED are probably incorrect. For other types of proteins, the error rates may be much higher. MetaCyc and Swiss-Prot have low error rates, but the best hits in these databases are often quite distant, so this protein's function may not be the same. TIGRFam has low error rates. Finally, many experimentally-characterized proteins are not in any of these databases. To find relevant papers, use PaperBLAST.

Protein Families and Features

1 50 100 137 PF00903: Glyoxalase" amino acids 4 to 112 (109 residues), 53.4 bits, see alignment E=3.3e-18 PF18029: Glyoxalase_6" amino acids 8 to 112 (105 residues), 26.5 bits, see alignment E=8.3e-10

Best Hits

Swiss-Prot: 68% identical to FOSA_PSEAE: Glutathione transferase FosA (fosA) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)

KEGG orthology group: None (inferred from 95% identity to pba:PSEBR_a1303)

Predicted SEED Role

"Fosfomycin resistance protein FosA" in subsystem Fosfomycin resistance

Sequence Analysis Tools

PaperBLAST (search for papers about homologs of this protein)

Search CDD (the Conserved Domains Database, which includes COG and superfam)

Search structures

Predict protein localization: PSORTb (Gram-negative bacteria)

Predict transmembrane helices and signal peptides: Phobius

Check the current SEED with FIGfam search

Find homologs in fast.genomics or the ENIGMA genome browser

See A0A159ZYE5 at UniProt or InterPro

Protein Sequence (137 amino acids)

>Pf6N2E2_2799 Fosfomycin resistance protein FosA (Pseudomonas fluorescens FW300-N2E2)
MLSGLNHLTLAVTDLDRSVGFYGELLQLRLEAKWDRGAYLSLPGLWLCLAFDPLRRPQPA
ADYTHYAFSITAEDFPALVARLNAAQVSSWRDNRSEGDSFYFLDPDGHKLEVHVGDLASR
LKACRQAPYAGMAFFTE